Valorization of Ethanol: Ruthenium-Catalyzed Guerbet and Sequential Functionalization Processes
We report a ruthenium-catalyzed tandem Guerbet–alkylation strategy for the valorization of ethanol. The products of ethanol upgrading (higher-order alcohols) undergo subsequent C–C bond forming reactions with four carbon pronucleophiles and one ylide. Studies into catalyst design led to the developm...
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Published in: | ACS catalysis Vol. 12; no. 11; pp. 6729 - 6736 |
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Main Authors: | , , , |
Format: | Journal Article |
Language: | English |
Published: |
United States
American Chemical Society
03-06-2022
American Chemical Society (ACS) |
Subjects: | |
Online Access: | Get full text |
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Summary: | We report a ruthenium-catalyzed tandem Guerbet–alkylation strategy for the valorization of ethanol. The products of ethanol upgrading (higher-order alcohols) undergo subsequent C–C bond forming reactions with four carbon pronucleophiles and one ylide. Studies into catalyst design led to the development of ClRu(5-Mebpi)(PPh3)2 (bpi = 1,3-bis(2′-pyridylimino)isoindolate) as a highly efficient catalyst for producing biofuels and value-added chemicals from ethanol via Guerbet and tandem Guerbet reactions. This catalyst affords 65% higher-order alcohols in short reaction times (2 h), providing the highest TON (155,890) and TOF (12,690 h–1 ) for a homogeneous catalyst reported to date. |
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Bibliography: | USDOE Office of Science (SC), Basic Energy Sciences (BES) SC0020191 |
ISSN: | 2155-5435 2155-5435 |
DOI: | 10.1021/acscatal.2c01570 |