Regulation of CD95 (Fas) Expression and Fas-Mediated Apoptotic Signaling in HLE B-3 Cells by 4-Hydroxynonenal

The Fas (apo/CD95) receptor which belongs to the TNF-α family is a transmembrane protein involved in the signaling for apoptosis through the extrinsic pathway. During this study, we have examined a correlation between intracellular levels of 4-HNE and expression of Fas in human lens epithelial (HLE...

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Bibliographic Details
Published in:	Biochemistry (Easton) Vol. 45; no. 40; pp. 12253 - 12264
Main Authors:	Li, Jie, Sharma, Rajendra, Patrick, Brad, Sharma, Abha, Jeyabal, Prince V. S, Reddy, Prasada M. R. V, Saini, Manjit K, Dwivedi, Seema, Dhanani, Shaheen, Ansari, Naseem H, Zimniak, Piotr, Awasthi, Sanjay, Awasthi, Yogesh C
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 10-10-2006
Subjects:	Aldehydes - metabolism Aldehydes - pharmacology Animals Apoptosis - physiology Caspase 3 Caspases - metabolism Cell Transformation, Viral Cells, Cultured Down-Regulation fas Receptor - biosynthesis fas Receptor - genetics Gene Expression Regulation - drug effects Humans Lens, Crystalline MAP Kinase Kinase 4 - metabolism Mice Signal Transduction - physiology
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