State of the Art in Respiratory Syncytial Virus Drug Discovery and Development
Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment options have been limited to palivizumab, a monoclonal antibody, approved for prophylaxis in high-risk infants and ribavirin with very limited eff...
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| Published in: | Journal of medicinal chemistry Vol. 62; no. 7; pp. 3206 - 3227 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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United States
American Chemical Society
11-04-2019
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| Abstract | Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment options have been limited to palivizumab, a monoclonal antibody, approved for prophylaxis in high-risk infants and ribavirin with very limited efficacy and significant safety concerns. This Perspective surveys the range of direct acting antiviral agents (DAAs) that target key steps in the viral life cycle. A number of approaches to DAAs have produced landmark clinical studies over the past few years, notably in fusion and nucleoside inhibitors, and an update of the clinical status of these compounds is provided. Non-nucleoside inhibitors of replication are reviewed in addition to inhibitors of other mechanisms, notably the RSV N and G proteins. This article will provide an informative perspective of the current status of drug discovery targeted at providing an effective therapy for RSV infection. |
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| AbstractList | Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment options have been limited to palivizumab, a monoclonal antibody, approved for prophylaxis in high-risk infants and ribavirin with very limited efficacy and significant safety concerns. This Perspective surveys the range of direct acting antiviral agents (DAAs) that target key steps in the viral life cycle. A number of approaches to DAAs have produced landmark clinical studies over the past few years, notably in fusion and nucleoside inhibitors, and an update of the clinical status of these compounds is provided. Non-nucleoside inhibitors of replication are reviewed in addition to inhibitors of other mechanisms, notably the RSV N and G proteins. This article will provide an informative perspective of the current status of drug discovery targeted at providing an effective therapy for RSV infection. |
| Author | Cockerill, G. Stuart Good, James A. D Mathews, Neil |
| AuthorAffiliation | ReViral Ltd Stevenage Bioscience Catalyst |
| AuthorAffiliation_xml | – name: ReViral Ltd – name: Stevenage Bioscience Catalyst |
| Author_xml | – sequence: 1 givenname: G. Stuart orcidid: 0000-0002-6340-0808 surname: Cockerill fullname: Cockerill, G. Stuart email: scockerill@reviral.co.uk – sequence: 2 givenname: James A. D surname: Good fullname: Good, James A. D – sequence: 3 givenname: Neil surname: Mathews fullname: Mathews, Neil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30411898$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Drug Discovery Humans Nucleocapsid Proteins - chemistry Nucleocapsid Proteins - metabolism Palivizumab - immunology Palivizumab - therapeutic use Respiratory Syncytial Virus Infections - drug therapy Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - drug effects Respiratory Syncytial Virus, Human - immunology Respiratory Syncytial Virus, Human - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - metabolism Small Molecule Libraries - therapeutic use Viral Fusion Proteins - chemistry Viral Fusion Proteins - metabolism |
| Title | State of the Art in Respiratory Syncytial Virus Drug Discovery and Development |
| URI | http://dx.doi.org/10.1021/acs.jmedchem.8b01361 https://www.ncbi.nlm.nih.gov/pubmed/30411898 https://search.proquest.com/docview/2132227980 |
| Volume | 62 |
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