Potential of the NBP Method for the Study of Alkylation Mechanisms: NBP as a DNA-Model

Alkylating agents are considered to be archetypal carcinogens. One suitable technique to evaluate the activity of alkylating compounds is the NBP assay. This method is based on the formation of a chromophore in the reaction between the alkylating agent and the nucleophile 4-(p-nitrobenzyl)­pyridine...

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Bibliographic Details

Published in:	Chemical research in toxicology Vol. 25; no. 6; pp. 1176 - 1191
Main Authors:	Gómez-Bombarelli, Rafael, González-Pérez, Marina, Calle, Emilio, Casado, Julio
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 18-06-2012
Subjects:	Alkylation Animals DNA - chemistry Humans Kinetics Models, Chemical Pyridines - chemical synthesis Pyridines - chemistry
Online Access:	Get full text
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