Antibacterial Salinaphthoquinones from a Strain of the Bacterium Salinispora arenicola Recovered from the Marine Sediments of St. Peter and St. Paul Archipelago, Brazil

• Published in: Journal of natural products (Washington, D.C.) Vol. 82; no. 7; pp. 1831 - 1838
• Main Authors: da Silva, Alison B, Silveira, Edilberto R, Wilke, Diego V, Ferreira, Elhton G, Costa-Lotufo, Leticia V, Torres, Maria Conceição M, Ayala, Alejandro Pedro, Costa, Wendell S, Canuto, Kirley M, de Araújo-Nobre, Alyne R, Araújo, Ana Jérsia, Filho, José Delano B. Marinho, Pessoa, Otilia Deusdenia L
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society and American Society of Pharmacognosy 26-07-2019
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/acs.jnatprod.9b00062

Salinaphthoquinones A–E (1–5) were isolated from a marine Salininispora arenicola strain, recovered from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the compounds were elucidated using a combination of spectroscopic (NMR, IR, HRESIMS) data, including single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway for 1–5 is proposed. Compounds 1 to 4 displayed moderate activity against Staphylococcus aureus and Enterococcus faecalis with MIC values of 125 to 16 μg/mL.