Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression

Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in Mutants with decreased susceptibility to MexAB-OprM inhibition by D13-9001 were identified, and these...

Full description

Saved in:

Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 63; no. 2
Main Authors:	Ranjitkar, Srijan, Jones, Adriana K, Mostafavi, Mina, Zwirko, Zachary, Iartchouk, Oleg, Barnes, S Whitney, Walker, John R, Willis, Thomas W, Lee, Patrick S, Dean, Charles R
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-02-2019
Subjects:	beta-Lactams beta-Lactams - pharmacology Imipenem - pharmacology Mechanisms of Resistance Microbial Sensitivity Tests Monobactams - pharmacology Piperidines Piperidines - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Quaternary Ammonium Compounds Quaternary Ammonium Compounds - pharmacology Tazobactam - pharmacology Thienamycins - pharmacology Transcriptome - genetics β-lactams Pseudomonas aeruginosa efflux pump inhibitor drug resistance mechanisms heavy metals efflux pumps
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!