Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression
Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in Mutants with decreased susceptibility to MexAB-OprM inhibition by D13-9001 were identified, and these...
Saved in:
| Published in: | Antimicrobial agents and chemotherapy Vol. 63; no. 2 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
American Society for Microbiology
01-02-2019
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in
Mutants with decreased susceptibility to MexAB-OprM inhibition by D13-9001 were identified, and these fell into two categories: those with alterations in the target MexB (F628L and ΔV177) and those with an alteration in a putative sensor kinase of unknown function, PA1438 (L172P). The alterations in MexB were consistent with reported structural studies of the D13-9001 interaction with MexB. The PA1438
alteration mediated a >150-fold upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437. We propose that these be renamed
and
for
ex
egulator and
ex
sensor, respectively. MexMN was shown to partner with the outer membrane channel protein OprM and to pump several β-lactams, monobactams, and tazobactam. Upregulated MexMN functionally replaced MexAB-OprM to efflux these compounds but was insusceptible to inhibition by D13-9001. MmnS
also mediated a decrease in susceptibility to imipenem and biapenem that was independent of MexMN-OprM. Expression of
, encoding the uptake channel for these compounds, was downregulated, suggesting that this channel is also part of the MmnSR regulon. Transcriptome sequencing (RNA-seq) of cells encoding MmnS
revealed, among other things, an interrelationship between the regulation of
and genes involved in heavy metal resistance. |
|---|---|
| AbstractList | Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in
Mutants with decreased susceptibility to MexAB-OprM inhibition by D13-9001 were identified, and these fell into two categories: those with alterations in the target MexB (F628L and ΔV177) and those with an alteration in a putative sensor kinase of unknown function, PA1438 (L172P). The alterations in MexB were consistent with reported structural studies of the D13-9001 interaction with MexB. The PA1438
alteration mediated a >150-fold upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437. We propose that these be renamed
and
for
ex
egulator and
ex
sensor, respectively. MexMN was shown to partner with the outer membrane channel protein OprM and to pump several β-lactams, monobactams, and tazobactam. Upregulated MexMN functionally replaced MexAB-OprM to efflux these compounds but was insusceptible to inhibition by D13-9001. MmnS
also mediated a decrease in susceptibility to imipenem and biapenem that was independent of MexMN-OprM. Expression of
, encoding the uptake channel for these compounds, was downregulated, suggesting that this channel is also part of the MmnSR regulon. Transcriptome sequencing (RNA-seq) of cells encoding MmnS
revealed, among other things, an interrelationship between the regulation of
and genes involved in heavy metal resistance. Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in Pseudomonas aeruginosa . Mutants with decreased susceptibility to MexAB-OprM inhibition by D13-9001 were identified, and these fell into two categories: those with alterations in the target MexB (F628L and ΔV177) and those with an alteration in a putative sensor kinase of unknown function, PA1438 (L172P). The alterations in MexB were consistent with reported structural studies of the D13-9001 interaction with MexB. The PA1438 L172P alteration mediated a >150-fold upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437. We propose that these be renamed mmnR and mmnS for M ex MN r egulator and M ex MN sensor, respectively. MexMN was shown to partner with the outer membrane channel protein OprM and to pump several β-lactams, monobactams, and tazobactam. Upregulated MexMN functionally replaced MexAB-OprM to efflux these compounds but was insusceptible to inhibition by D13-9001. MmnS L172P also mediated a decrease in susceptibility to imipenem and biapenem that was independent of MexMN-OprM. Expression of oprD , encoding the uptake channel for these compounds, was downregulated, suggesting that this channel is also part of the MmnSR regulon. Transcriptome sequencing (RNA-seq) of cells encoding MmnS L172P revealed, among other things, an interrelationship between the regulation of mexMN and genes involved in heavy metal resistance. Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. D13-9001 specifically inhibits MexAB-OprM in Pseudomonas aeruginosa. Mutants with decreased susceptibility to MexAB-OprM inhibition by D13-9001 were identified, and these fell into two categories: those with alterations in the target MexB (F628L and ΔV177) and those with an alteration in a putative sensor kinase of unknown function, PA1438 (L172P). The alterations in MexB were consistent with reported structural studies of the D13-9001 interaction with MexB. The PA1438L172P alteration mediated a >150-fold upregulation of MexMN pump gene expression and a >50-fold upregulation of PA1438 and the neighboring response regulator gene, PA1437. We propose that these be renamed mmnR and mmnS for MexMN regulator and MexMN sensor, respectively. MexMN was shown to partner with the outer membrane channel protein OprM and to pump several β-lactams, monobactams, and tazobactam. Upregulated MexMN functionally replaced MexAB-OprM to efflux these compounds but was insusceptible to inhibition by D13-9001. MmnSL172P also mediated a decrease in susceptibility to imipenem and biapenem that was independent of MexMN-OprM. Expression of oprD, encoding the uptake channel for these compounds, was downregulated, suggesting that this channel is also part of the MmnSR regulon. Transcriptome sequencing (RNA-seq) of cells encoding MmnSL172P revealed, among other things, an interrelationship between the regulation of mexMN and genes involved in heavy metal resistance. |
| Author | Jones, Adriana K Ranjitkar, Srijan Lee, Patrick S Walker, John R Zwirko, Zachary Willis, Thomas W Barnes, S Whitney Mostafavi, Mina Dean, Charles R Iartchouk, Oleg |
| Author_xml | – sequence: 1 givenname: Srijan surname: Ranjitkar fullname: Ranjitkar, Srijan organization: Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA – sequence: 2 givenname: Adriana K surname: Jones fullname: Jones, Adriana K organization: Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA – sequence: 3 givenname: Mina surname: Mostafavi fullname: Mostafavi, Mina organization: Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA – sequence: 4 givenname: Zachary surname: Zwirko fullname: Zwirko, Zachary organization: Biotherapeutic and Analytical Technologies, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA – sequence: 5 givenname: Oleg surname: Iartchouk fullname: Iartchouk, Oleg organization: Biotherapeutic and Analytical Technologies, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA – sequence: 6 givenname: S Whitney surname: Barnes fullname: Barnes, S Whitney organization: Genomics Institute of Novartis Research Foundation (GNF), San Diego, California, USA – sequence: 7 givenname: John R surname: Walker fullname: Walker, John R organization: Genomics Institute of Novartis Research Foundation (GNF), San Diego, California, USA – sequence: 8 givenname: Thomas W surname: Willis fullname: Willis, Thomas W organization: Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA – sequence: 9 givenname: Patrick S surname: Lee fullname: Lee, Patrick S organization: Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA – sequence: 10 givenname: Charles R orcidid: 0000-0001-9858-9818 surname: Dean fullname: Dean, Charles R email: charlesr.dean@novartis.com organization: Infectious Diseases, Novartis Institutes for Biomedical Research, Emeryville, California, USA charlesr.dean@novartis.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30420483$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks1uEzEUhQdURNMCK9bIy0Ziij32_HWBlKYBKjVNFNq15XiuE1czdrBnQvtaPAjPhKdJK1iwsmwff-dc6xxFB8YaiKL3BJ8SkhSfRqPxKSY5KWJSvIwGBJdFnKVldhANMM6ymBWYHUZH3t_hsE9L_Do6pJglmBV08OLdjXAraNHJFO7PhzESpkITperuPj4XHio0BbkWRvvGowuQDoTXZoXaNfQykK3eggHvkVVPh-EtmnfNBl2atV7q1jp0QWhcYkyQNmjuoatsY43wSIDrVtpYL9B8NCNn6NZIuwXXWwh0DT_RwtaAVECEfNPreLZx0x6ytwmmv3_FV0K2IuTrs4dXAVCjBay6WgTvBzTWTna6H7Exi-9DNLamdbaue5NHKprcb1yYQVvzJnqlRO3h7X49jm6_TG7G3-Kr2dfL8egqFpQVbVxQkatUqiVkUmYFy1VGMKMZzSBL2DJRTKV5Ula0qColUlEmlcxoVeWEsQrKnB5Hn3fcTbdsoJIQIomab5xuhHvgVmj-743Ra76yW57RNA1eAXCyBzj7owPf8kZ7CXUtDNjO84TQJKesLJMg_biTSme9d6CebQjmfYV4qBB_rBAnRZAPd3Lhm4Tf2c6Z8BP_0374e4xn8FO_6B9K6dJo |
| CitedBy_id | crossref_primary_10_3390_ijms232415779 crossref_primary_10_1128_AAC_00784_19 crossref_primary_10_3390_antibiotics12081304 crossref_primary_10_1016_j_mib_2022_102179 crossref_primary_10_1128_aac_00672_22 crossref_primary_10_1002_chem_202000213 crossref_primary_10_1016_j_watres_2022_119060 crossref_primary_10_1371_journal_pgen_1011325 crossref_primary_10_3389_fcimb_2021_665759 crossref_primary_10_1128_spectrum_01026_21 crossref_primary_10_3390_antibiotics10070863 crossref_primary_10_1021_jacsau_2c00532 crossref_primary_10_1128_spectrum_00057_22 |
| Cites_doi | 10.1128/JB.00837-06 10.1038/srep40208 10.1111/j.1365-2958.2004.04210.x 10.1099/mic.0.26460-0 10.1038/srep41114 10.1128/AAC.01252-10 10.1128/AAC.49.5.1782-1786.2005 10.1128/JB.00073-09 10.1016/j.mimet.2005.06.001 10.1111/j.1574-6968.2010.02063.x 10.12688/f1000research.7563.2 10.1128/JB.184.8.2319-2323.2002 10.1128/AAC.45.1.105-116.2001 10.1093/femsle/fnw166 10.1016/j.bmcl.2018.01.006 10.1128/AAC.36.9.1847 10.1093/jac/dkr543 10.1128/JB.187.5.1763-1772.2005 10.1111/mmi.13346 10.1128/AAC.05417-11 10.1128/AAC.00704-06 10.1128/JB.184.15.4168-4176.2002 10.1128/AAC.49.2.791-793.2005 10.1128/AAC.00253-09 10.1099/00221287-146-1-185 10.1099/mic.0.028993-0 10.1128/AAC.01024-08 10.1111/j.1758-2229.2010.00175.x 10.1021/ja00170a016 10.1021/acs.jmedchem.7b00377 10.1371/journal.pone.0034067 10.1128/MMBR.67.4.593-656.2003 10.1128/JB.182.5.1410-1414.2000 10.1006/plas.1994.1028 10.1371/journal.ppat.1005932 10.1093/nar/gkv1227 10.1038/nature12300 10.1016/S0924-8579(03)00009-8 10.1128/JB.188.5.1847-1855.2006 10.1038/nmeth.3252 10.1046/j.1365-2958.1996.281397.x 10.1128/JB.00095-07 10.1155/2012/575193 10.1016/S0378-1119(98)00130-9 10.1128/JB.01342-06 10.1128/AAC.48.5.1797-1802.2004 10.1128/AAC.43.12.2975 10.1128/AAC.02284-12 10.1111/cbdd.12104 10.1016/j.bmc.2007.07.039 10.3389/fmicb.2015.00377 10.1128/AAC.02622-15 10.1099/mic.0.069286-0 10.1074/jbc.M312080200 10.1128/IAI.00338-07 10.1128/CMR.00117-14 10.1371/journal.pone.0033777 10.1038/nmeth.4197 10.1016/0076-6879(94)35157-0 10.1186/s13059-014-0550-8 10.1128/AAC.49.2.565-570.2005 10.1007/s00284-013-0363-0 10.1111/j.1432-1033.1990.tb19265.x 10.1371/journal.pone.0042657 10.1128/AAC.01072-08 10.1111/j.1348-0421.2005.tb03696.x 10.1136/thoraxjnl-2015-208027 10.3389/fmicb.2011.00065 10.1128/AAC.00846-12 10.1128/JB.01534-10 10.3390/genes7120126 |
| ContentType | Journal Article |
| Copyright | Copyright © 2019 American Society for Microbiology. Copyright © 2019 American Society for Microbiology. 2019 American Society for Microbiology |
| Copyright_xml | – notice: Copyright © 2019 American Society for Microbiology. – notice: Copyright © 2019 American Society for Microbiology. 2019 American Society for Microbiology |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1128/AAC.01718-18 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology Pharmacy, Therapeutics, & Pharmacology |
| DocumentTitleAlternate | Resistance to Efflux Pump Inhibition in , , Ranjitkar et al Resistance to Efflux Pump Inhibition in P. aeruginosa |
| EISSN | 1098-6596 |
| ExternalDocumentID | 10_1128_AAC_01718_18 01718-18 30420483 |
| Genre | Journal Article |
| GroupedDBID | --- .55 .GJ 0R~ 23M 2WC 39C 3O- 4.4 53G 5GY 5RE 5VS 6J9 ACGFO ADBBV AENEX AGNAY AGVNZ AI. ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW C1A CGR CS3 CUY CVF DIK E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HH5 HYE HZ~ H~9 J5H K-O KQ8 L7B LSO MVM NEJ NPM O9- OK1 P2P RHF RHI RNS RPM RSF TR2 UHB VH1 W2D W8F WH7 WHG WOQ X7M X7N XOL Y6R ZGI ZXP ~A~ - 0R 55 AAPBV ABFLS ADACO BXI HZ ZA5 AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-a348t-83a7f5cfbe6cc6847f61043636e624b2f4f5729d38ddfa5a92dc63dd7144de973 |
| IEDL.DBID | RPM |
| ISSN | 0066-4804 |
| IngestDate | Tue Sep 17 21:07:49 EDT 2024 Fri Oct 25 08:51:31 EDT 2024 Thu Nov 21 21:50:12 EST 2024 Tue Dec 28 13:58:57 EST 2021 Sat Sep 28 08:30:13 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | β-lactams Pseudomonas aeruginosa efflux pump inhibitor drug resistance mechanisms heavy metals efflux pumps |
| Language | English |
| License | Copyright © 2019 American Society for Microbiology. All Rights Reserved. https://doi.org/10.1128/ASMCopyrightv2 All Rights Reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a348t-83a7f5cfbe6cc6847f61043636e624b2f4f5729d38ddfa5a92dc63dd7144de973 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 S.R. and A.K.J. contributed equally to this article. Citation Ranjitkar S, Jones AK, Mostafavi M, Zwirko Z, Iartchouk O, Barnes SW, Walker JR, Willis TW, Lee PS, Dean CR. 2019. Target (MexB)- and efflux-based mechanisms decreasing the effectiveness of the efflux pump inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: uncovering a new role for MexMN-OprM in efflux of β-lactams and a novel regulatory circuit (MmnRS) controlling MexMN expression. Antimicrob Agents Chemother 63:e01718-18. https://doi.org/10.1128/AAC.01718-18. Present address: Srijan Ranjitkar, Epizyme, Cambridge, Massachusetts, USA. |
| ORCID | 0000-0001-9858-9818 |
| OpenAccessLink | https://aac.asm.org/content/aac/63/2/e01718-18.full.pdf |
| PMID | 30420483 |
| PQID | 2132734992 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6355610 proquest_miscellaneous_2132734992 crossref_primary_10_1128_AAC_01718_18 asm2_journals_10_1128_AAC_01718_18 pubmed_primary_30420483 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-02-01 |
| PublicationDateYYYYMMDD | 2019-02-01 |
| PublicationDate_xml | – month: 02 year: 2019 text: 2019-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: 1752 N St., N.W., Washington, DC |
| PublicationTitle | Antimicrobial agents and chemotherapy |
| PublicationTitleAbbrev | Antimicrob Agents Chemother |
| PublicationTitleAlternate | Antimicrob Agents Chemother |
| PublicationYear | 2019 |
| Publisher | American Society for Microbiology |
| Publisher_xml | – name: American Society for Microbiology |
| References | Morita, Y, Cao, L, Gould, VC, Avison, MB, Poole, K (B11) 2006; 188 Teitzel, GM, Geddie, A, De Long, SK, Kirisits, MJ, Whiteley, M, Parsek, MR (B48) 2006; 188 Westbrock-Wadman, S, Sherman, DR, Hickey, MJ, Coulter, SN, Zhu, YQ, Warrener, P, Nguyen, LY, Shawar, RM, Folger, KR, Stover, CK (B27) 1999; 43 Kriengkauykiat, J, Porter, E, Lomovskaya, O, Wong-Beringer, A (B30) 2005; 49 Mima, T, Sekiya, H, Mizushima, T, Kuroda, T, Tsuchiya, T (B37) 2005; 49 Purssell, A, Poole, K (B17) 2013; 159 Srikumar, R, Paul, CJ, Poole, K (B5) 2000; 182 Sadeghifard, N, Valizadeh, A, Zolfaghary, MR, Maleki, MH, Maleki, A, Mohebi, R, Ghafourian, S, Khosravi, A (B9) 2012; 2012 Hoang, TT, Karkhoff-Schweizer, RR, Kutchma, AJ, Schweizer, HP (B71) 1998; 212 El’Garch, F, Jeannot, K, Hocquet, D, Llanes-Barakat, C, Plesiat, P (B25) 2007; 51 Jahandideh, S (B23) 2013; 81 Morita, Y, Gilmour, C, Metcalf, D, Poole, K (B14) 2009; 191 Poole, K (B38) 2011; 2 Higgins, PG, Fluit, AC, Milatovic, D, Verhoef, J, Schmitz, FJ (B18) 2003; 21 Lomovskaya, O, Warren, MS, Lee, A, Galazzo, J, Fronko, R, Lee, M, Blais, J, Cho, D, Chamberland, S, Renau, T, Leger, R, Hecker, S, Watkins, W, Hoshino, K, Ishida, H, Lee, VJ (B29) 2001; 45 Nishino, K, Honda, T, Yamaguchi, A (B40) 2005; 187 Richardot, C, Juarez, P, Jeannot, K, Patry, I, Plesiat, P, Llanes, C (B22) 2016; 60 MacEachran, DP, Ye, S, Bomberger, JM, Hogan, DA, Swiatecka-Urban, A, Stanton, BA, O'Toole, GA (B72) 2007; 75 DeSarbre, E, Page, MGP (B73) 2008 Yamamoto, M, Ueda, A, Kudo, M, Matsuo, Y, Fukushima, J, Nakae, T, Kaneko, T, Ishigatsubo, Y (B16) 2009; 155 Baranova, N, Nikaido, H (B39) 2002; 184 Fraud, S, Campigotto, AJ, Chen, Z, Poole, K (B58) 2008; 52 Morita, Y, Sobel, ML, Poole, K (B15) 2006; 188 Nakashima, R, Sakurai, K, Yamasaki, S, Hayashi, K, Nagata, C, Hoshino, K, Onodera, Y, Nishino, K, Yamaguchi, A (B32) 2013; 500 Nikaido, H (B1) 2003; 67 Braz, VS, Furlan, JP, Fernandes, AF, Stehling, EG (B7) 2016; 363 Caughlan, RE, Jones, AK, Delucia, AM, Woods, AL, Xie, L, Ma, B, Barnes, SW, Walker, JR, Sprague, ER, Yang, X, Dean, CR (B34) 2012; 56 Srinivasan, VB, Rajamohan, G (B45) 2013; 57 Reinhart, AA, Oglesby-Sherrouse, AG (B52) 2016; 7 Jansons, I, Touchie, G, Sharp, R, Almquist, K, Farinha, MA, Lam, JS, Kropinski, AM (B70) 1994; 31 Case, DA, Darden, TA, Cheatham, TE, Simmerling, CL, Wang, J, Duke, RE, Luo, R, Crowley, M, Walker, RC, Zhang, W, Merz, KM, Wang, B, Hayik, S, Roitberg, A, Seabra, G, Kolossváry, I, Wong, KF, Paesani, F, Vanicek, J, Wu, X, Brozell, SR, Steinbrecher, T, Gohlke, H, Yang, L, Tan, C, Mongan, J, Hornak, V, Cui, G, Mathews, DH, Seetin, MG, Sagui, C, Babin, V, Kollman, PA (B67) 2008 Perron, K, Caille, O, Rossier, C, Van Delden, C, Dumas, J-L, Köhler, T (B49) 2004; 279 de Lorenzo, V, Timmis, KN (B69) 1994; 235 Reck, F, Bermingham, A, Blais, J, Capka, V, Cariaga, T, Casarez, A, Colvin, R, Dean, CR, Fekete, A, Gong, W, Growcott, E, Guo, H, Jones, AK, Li, C, Li, F, Lin, X, Lindvall, M, Lopez, S, McKenney, D, Metzger, L, Moser, HE, Prathapam, R, Rasper, D, Rudewicz, P, Sethuraman, V, Shen, X, Shaul, J, Simmons, RL, Tashiro, K, Tang, D, Tjandra, M, Turner, N, Uehara, T, Vitt, C, Whitebread, S, Yifru, A, Zang, X, Zhu, Q (B33) 2018; 28 Petrova, OE, Garcia-Alcalde, F, Zampaloni, C, Sauer, K (B62) 2017; 7 Cao, L, Srikumar, R, Poole, K (B8) 2004; 53 Nishino, K, Yamaguchi, A (B43) 2002; 184 Sobel, ML, Hocquet, D, Cao, L, Plesiat, P, Poole, K (B12) 2005; 49 Winsor, GL, Griffiths, EJ, Lo, R, Dhillon, BK, Shay, JA, Brinkman, FS (B4) 2016; 44 Caughlan, RE, Sriram, S, Daigle, DM, Woods, AL, Buco, J, Peterson, RL, Dzink-Fox, J, Walker, S, Dean, CR (B13) 2009; 53 Venter, H, Mowla, R, Ohene-Agyei, T, Ma, S (B3) 2015; 6 Caille, O, Rossier, C, Perron, K (B53) 2007; 189 Maseda, H, Uwate, M, Nakae, T (B20) 2010; 311 Ochsner, UA, Johnson, Z, Vasil, ML (B51) 2000; 146 Love, MI, Huber, W, Anders, S (B65) 2014; 15 Ruzin, A, Keeney, D, Bradford, PA (B61) 2005; 49 Zumft, WG, Viebrock-Sambale, A, Braun, C (B50) 1990; 192 Srinivasan, VB, Vaidyanathan, V, Mondal, A, Rajamohan, G (B46) 2012; 7 Prickett, MH, Hauser, AR, McColley, SA, Cullina, J, Potter, E, Powers, C, Jain, M (B24) 2016; 72 Masuda, N, Ohya, S (B68) 1992; 36 Balibar, CJ, Iwanowicz, D, Dean, CR (B28) 2013; 67 Huber, W, Carey, VJ, Gentleman, R, Anders, S, Carlson, M, Carvalho, BS, Bravo, HC, Davis, S, Gatto, L, Girke, T, Gottardo, R, Hahne, F, Hansen, KD, Irizarry, RA, Lawrence, M, Love, MI, MacDonald, J, Obenchain, V, Oleś, AK, Pagès, H, Reyes, A, Shannon, P, Smyth, GK, Tenenbaum, D, Waldron, L, Morgan, M (B66) 2015; 12 Nyfeler, B, Hoepfner, D, Palestrant, D, Kirby, CA, Whitehead, L, Yu, R, Deng, G, Caughlan, RE, Woods, AL, Jones, AK, Barnes, SW, Walker, JR, Gaulis, S, Hauy, E, Brachmann, SM, Krastel, P, Studer, C, Riedl, R, Estoppey, D, Aust, T, Movva, NR, Wang, Z, Salcius, M, Michaud, GA, McAllister, G, Murphy, LO, Tallarico, JA, Wilson, CJ, Dean, CR (B60) 2012; 7 Eguchi, Y, Oshima, T, Mori, H, Aono, R, Yamamoto, K, Ishihama, A, Utsumi, R (B42) 2003; 149 Lampilas, M, Rowlands, DA, Kebsi, A, Ledoussal, B, Pierres, C (B74) 2011 Piizzi, G, Parker, DT, Peng, Y, Dobler, M, Patnaik, A, Wattanasin, S, Liu, E, Lenoir, F, Nunez, J, Kerrigan, J, McKenney, D, Osborne, C, Yu, D, Lanieri, L, Bojkovic, J, Dzink-Fox, J, Lilly, MD, Sprague, ER, Lu, Y, Wang, H, Ranjitkar, S, Xie, L, Wang, B, Glick, M, Hamann, LG, Tommasi, R, Yang, X, Dean, CR (B35) 2017; 60 Mooij, MJ, O’Connor, HF, Tian, ZX, Wang, YP, Adams, C, Morrissey, JP, O’Gara, F (B21) 2010; 2 Soneson, C, Love, MI, Robinson, MD (B64) 2015; 4 Chen, W, Wang, D, Zhou, W, Sang, H, Liu, X, Ge, Z, Zhang, J, Lan, L, Yang, CG, Chen, H (B10) 2016; 100 Tian, Z-X, Yi, X-X, Cho, A, O’Gara, F, Wang, Y-P (B44) 2016; 12 Choi, KH, Kumar, A, Schweizer, HP (B59) 2006; 64 Muller, C, Plesiat, P, Jeannot, K (B47) 2011; 55 Leblanc, SK, Oates, CW, Raivio, TL (B41) 2011; 193 Poole, K, Gotoh, N, Tsujimoto, H, Zhao, Q, Wada, A, Yamasaki, T, Neshat, S, Yamagishi, J, Li, XZ, Nishino, T (B19) 1996; 21 Li, XZ, Plesiat, P, Nikaido, H (B2) 2015; 28 Buyck, JM, Guenard, S, Plesiat, P, Tulkens, PM, Van Bambeke, F (B55) 2012; 67 Hunter, CA, Sanders, JKM (B36) 1990; 112 Chalhoub, H, Pletzer, D, Weingart, H, Braun, Y, Tunney, MM, Elborn, JS, Rodriguez-Villalobos, H, Plesiat, P, Kahl, BC, Denis, O, Winterhalter, M, Tulkens, PM, Van Bambeke, F (B56) 2017; 7 Patro, R, Duggal, G, Love, MI, Irizarry, RA, Kingsford, C (B63) 2017; 14 Llanes, C, Hocquet, D, Vogne, C, Benali-Baitich, D, Neuwirth, C, Plésiat, P (B6) 2004; 48 Lau, CH, Fraud, S, Jones, M, Peterson, SN, Poole, K (B26) 2012; 56 Balasubramanian, D, Schneper, L, Merighi, M, Smith, R, Narasimhan, G, Lory, S, Mathee, K (B54) 2012; 7 Yoshida, K, Nakayama, K, Ohtsuka, M, Kuru, N, Yokomizo, Y, Sakamoto, A, Takemura, M, Hoshino, K, Kanda, H, Nitanai, H, Namba, K, Yoshida, K, Imamura, Y, Zhang, JZ, Lee, VJ, Watkins, WJ (B31) 2007; 15 Vettoretti, L, Plesiat, P, Muller, C, El Garch, F, Phan, G, Attree, I, Ducruix, A, Llanes, C (B57) 2009; 53 e_1_3_3_50_2 e_1_3_3_75_2 e_1_3_3_71_2 e_1_3_3_16_2 e_1_3_3_18_2 e_1_3_3_39_2 e_1_3_3_12_2 e_1_3_3_37_2 e_1_3_3_58_2 e_1_3_3_14_2 e_1_3_3_35_2 e_1_3_3_56_2 e_1_3_3_33_2 e_1_3_3_54_2 e_1_3_3_10_2 e_1_3_3_31_2 e_1_3_3_52_2 e_1_3_3_73_2 e_1_3_3_40_2 e_1_3_3_61_2 e_1_3_3_5_2 e_1_3_3_7_2 e_1_3_3_9_2 e_1_3_3_27_2 e_1_3_3_29_2 e_1_3_3_23_2 e_1_3_3_48_2 e_1_3_3_69_2 e_1_3_3_25_2 e_1_3_3_46_2 e_1_3_3_67_2 e_1_3_3_44_2 e_1_3_3_65_2 e_1_3_3_3_2 e_1_3_3_21_2 e_1_3_3_42_2 e_1_3_3_63_2 e_1_3_3_51_2 e_1_3_3_74_2 e_1_3_3_70_2 e_1_3_3_17_2 e_1_3_3_19_2 e_1_3_3_38_2 e_1_3_3_13_2 e_1_3_3_36_2 e_1_3_3_59_2 e_1_3_3_15_2 e_1_3_3_34_2 e_1_3_3_57_2 e_1_3_3_32_2 e_1_3_3_55_2 e_1_3_3_11_2 e_1_3_3_30_2 e_1_3_3_53_2 e_1_3_3_72_2 e_1_3_3_62_2 e_1_3_3_60_2 e_1_3_3_6_2 Case DA (e_1_3_3_68_2) 2008 e_1_3_3_8_2 e_1_3_3_28_2 e_1_3_3_49_2 e_1_3_3_24_2 e_1_3_3_47_2 e_1_3_3_26_2 e_1_3_3_45_2 e_1_3_3_2_2 e_1_3_3_20_2 e_1_3_3_43_2 e_1_3_3_66_2 e_1_3_3_4_2 e_1_3_3_22_2 e_1_3_3_41_2 e_1_3_3_64_2 |
| References_xml | – volume: 188 start-page: 7242 year: 2006 end-page: 7256 ident: B48 article-title: Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosa publication-title: J Bacteriol doi: 10.1128/JB.00837-06 contributor: fullname: Parsek, MR – volume: 7 start-page: 40208 year: 2017 ident: B56 article-title: Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic publication-title: Sci Rep doi: 10.1038/srep40208 contributor: fullname: Van Bambeke, F – volume: 53 start-page: 1423 year: 2004 end-page: 1436 ident: B8 article-title: MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719 publication-title: Mol Microbiol doi: 10.1111/j.1365-2958.2004.04210.x contributor: fullname: Poole, K – volume: 149 start-page: 2819 year: 2003 end-page: 2828 ident: B42 article-title: Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli publication-title: Microbiology doi: 10.1099/mic.0.26460-0 contributor: fullname: Utsumi, R – volume: 7 start-page: 41114 year: 2017 ident: B62 article-title: Comparative evaluation of rRNA depletion procedures for the improved analysis of bacterial biofilm and mixed pathogen culture transcriptomes publication-title: Sci Rep doi: 10.1038/srep41114 contributor: fullname: Sauer, K – volume: 55 start-page: 1211 year: 2011 end-page: 1221 ident: B47 article-title: A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and β-lactams in Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01252-10 contributor: fullname: Jeannot, K – volume: 49 start-page: 1782 year: 2005 end-page: 1786 ident: B12 article-title: Mutations in PA3574 (nalD) lead to increased MexAB-OprM expression and multidrug resistance in laboratory and clinical isolates of Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.5.1782-1786.2005 contributor: fullname: Poole, K – volume: 191 start-page: 4966 year: 2009 end-page: 4975 ident: B14 article-title: Translational control of the antibiotic inducibility of the PA5471 gene required for mexXY multidrug efflux gene expression in Pseudomonas aeruginosa publication-title: J Bacteriol doi: 10.1128/JB.00073-09 contributor: fullname: Poole, K – volume: 64 start-page: 391 year: 2006 end-page: 397 ident: B59 article-title: A 10-min method for preparation of highly electrocompetent Pseudomonas aeruginosa cells: application for DNA fragment transfer between chromosomes and plasmid transformation publication-title: J Microbiol Methods doi: 10.1016/j.mimet.2005.06.001 contributor: fullname: Schweizer, HP – volume: 311 start-page: 36 year: 2010 end-page: 43 ident: B20 article-title: Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa publication-title: FEMS Microbiol Lett doi: 10.1111/j.1574-6968.2010.02063.x contributor: fullname: Nakae, T – volume: 4 start-page: 1521 year: 2015 ident: B64 article-title: Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences publication-title: F1000Res doi: 10.12688/f1000research.7563.2 contributor: fullname: Robinson, MD – volume: 184 start-page: 2319 year: 2002 end-page: 2323 ident: B43 article-title: EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli publication-title: J Bacteriol doi: 10.1128/JB.184.8.2319-2323.2002 contributor: fullname: Yamaguchi, A – volume: 45 start-page: 105 year: 2001 end-page: 116 ident: B29 article-title: Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.45.1.105-116.2001 contributor: fullname: Lee, VJ – volume: 363 start-page: fnw166 year: 2016 ident: B7 article-title: Mutations in NalC induce MexAB-OprM overexpression resulting in high level of aztreonam resistance in environmental isolates of Pseudomonas aeruginosa publication-title: FEMS Microbiol Lett doi: 10.1093/femsle/fnw166 contributor: fullname: Stehling, EG – volume: 28 start-page: 748 year: 2018 end-page: 755 ident: B33 article-title: Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae—identification of LYS228 publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2018.01.006 contributor: fullname: Zhu, Q – volume: 36 start-page: 1847 year: 1992 end-page: 1851 ident: B68 article-title: Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.36.9.1847 contributor: fullname: Ohya, S – volume: 67 start-page: 771 year: 2012 end-page: 775 ident: B55 article-title: Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis publication-title: J Antimicrob Chemother doi: 10.1093/jac/dkr543 contributor: fullname: Van Bambeke, F – volume: 187 start-page: 1763 year: 2005 end-page: 1772 ident: B40 article-title: Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system publication-title: J Bacteriol doi: 10.1128/JB.187.5.1763-1772.2005 contributor: fullname: Yamaguchi, A – volume: 100 start-page: 749 year: 2016 end-page: 758 ident: B10 article-title: Novobiocin binding to NalD induces the expression of the MexAB-OprM pump in Pseudomonas aeruginosa publication-title: Mol Microbiol doi: 10.1111/mmi.13346 contributor: fullname: Chen, H – year: 2011 ident: B74 article-title: Nitrogenous heterocyclic compounds, preparation thereof and use thereof as antibacterial medicaments contributor: fullname: Pierres, C – volume: 56 start-page: 17 year: 2012 end-page: 27 ident: B34 article-title: Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the Gram-negative pathogen Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.05417-11 contributor: fullname: Dean, CR – volume: 51 start-page: 1016 year: 2007 end-page: 1021 ident: B25 article-title: Cumulative effects of several nonenzymatic mechanisms on the resistance of Pseudomonas aeruginosa to aminoglycosides publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00704-06 contributor: fullname: Plesiat, P – volume: 184 start-page: 4168 year: 2002 end-page: 4176 ident: B39 article-title: The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate publication-title: J Bacteriol doi: 10.1128/JB.184.15.4168-4176.2002 contributor: fullname: Nikaido, H – volume: 49 start-page: 791 year: 2005 end-page: 793 ident: B61 article-title: AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.2.791-793.2005 contributor: fullname: Bradford, PA – volume: 53 start-page: 5015 year: 2009 end-page: 5021 ident: B13 article-title: Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00253-09 contributor: fullname: Dean, CR – volume: 146 start-page: 185 year: 2000 end-page: 198 ident: B51 article-title: Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa publication-title: Microbiology doi: 10.1099/00221287-146-1-185 contributor: fullname: Vasil, ML – year: 2008 ident: B73 article-title: Combination medicaments for treating bacterial infections contributor: fullname: Page, MGP – volume: 155 start-page: 3312 year: 2009 end-page: 3321 ident: B16 article-title: Role of MexZ and PA5471 in transcriptional regulation of mexXY in Pseudomonas aeruginosa publication-title: Microbiology doi: 10.1099/mic.0.028993-0 contributor: fullname: Ishigatsubo, Y – volume: 53 start-page: 1987 year: 2009 end-page: 1997 ident: B57 article-title: Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01024-08 contributor: fullname: Llanes, C – volume: 2 start-page: 461 year: 2010 end-page: 464 ident: B21 article-title: Antibiotic selection leads to inadvertent selection of nfxC-type phenotypic mutants in Pseudomonas aeruginosa publication-title: Environ Microbiol Rep doi: 10.1111/j.1758-2229.2010.00175.x contributor: fullname: O’Gara, F – volume: 112 start-page: 5525 year: 1990 end-page: 5534 ident: B36 article-title: The nature of pi-pi interactions publication-title: J Am Chem Soc doi: 10.1021/ja00170a016 contributor: fullname: Sanders, JKM – volume: 60 start-page: 5002 year: 2017 end-page: 5014 ident: B35 article-title: Design, synthesis, and properties of a potent inhibitor of Pseudomonas aeruginosa deacetylase LpxC publication-title: J Med Chem doi: 10.1021/acs.jmedchem.7b00377 contributor: fullname: Dean, CR – volume: 7 year: 2012 ident: B54 article-title: The regulatory repertoire of Pseudomonas aeruginosa AmpC β-lactamase regulator AmpR includes virulence genes publication-title: PLoS One doi: 10.1371/journal.pone.0034067 contributor: fullname: Mathee, K – volume: 67 start-page: 593 year: 2003 end-page: 656 ident: B1 article-title: Molecular basis of bacterial outer membrane permeability revisited publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.67.4.593-656.2003 contributor: fullname: Nikaido, H – volume: 182 start-page: 1410 year: 2000 end-page: 1414 ident: B5 article-title: Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa publication-title: J Bacteriol doi: 10.1128/JB.182.5.1410-1414.2000 contributor: fullname: Poole, K – volume: 31 start-page: 265 year: 1994 end-page: 274 ident: B70 article-title: Deletion and transposon mutagenesis and sequence analysis of the pRO1600 OriR region found in the broad-host-range plasmids of the pQF series publication-title: Plasmid doi: 10.1006/plas.1994.1028 contributor: fullname: Kropinski, AM – volume: 12 year: 2016 ident: B44 article-title: CpxR activates MexAB-OprM efflux pump expression and enhances antibiotic resistance in both laboratory and clinical nalB-type isolates of Pseudomonas aeruginosa publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1005932 contributor: fullname: Wang, Y-P – volume: 44 start-page: D646 year: 2016 end-page: D653 ident: B4 article-title: Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv1227 contributor: fullname: Brinkman, FS – volume: 500 start-page: 102 year: 2013 end-page: 106 ident: B32 article-title: Structural basis for the inhibition of bacterial multidrug exporters publication-title: Nature doi: 10.1038/nature12300 contributor: fullname: Yamaguchi, A – volume: 21 start-page: 409 year: 2003 end-page: 413 ident: B18 article-title: Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa publication-title: Int J Antimicrob Agents doi: 10.1016/S0924-8579(03)00009-8 contributor: fullname: Schmitz, FJ – volume: 188 start-page: 1847 year: 2006 end-page: 1855 ident: B15 article-title: Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product publication-title: J Bacteriol doi: 10.1128/JB.188.5.1847-1855.2006 contributor: fullname: Poole, K – volume: 12 start-page: 115 year: 2015 end-page: 121 ident: B66 article-title: Orchestrating high-throughput genomic analysis with Bioconductor publication-title: Nat Methods doi: 10.1038/nmeth.3252 contributor: fullname: Morgan, M – volume: 21 start-page: 713 year: 1996 end-page: 724 ident: B19 article-title: Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa publication-title: Mol Microbiol doi: 10.1046/j.1365-2958.1996.281397.x contributor: fullname: Nishino, T – volume: 189 start-page: 4561 year: 2007 end-page: 4568 ident: B53 article-title: A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa publication-title: J Bacteriol doi: 10.1128/JB.00095-07 contributor: fullname: Perron, K – volume: 2012 start-page: 575193 year: 2012 ident: B9 article-title: Relationship between the presence of the nalC mutation and multidrug resistance in Pseudomonas aeruginosa publication-title: Int J Microbiol doi: 10.1155/2012/575193 contributor: fullname: Khosravi, A – volume: 212 start-page: 77 year: 1998 end-page: 86 ident: B71 article-title: A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants publication-title: Gene doi: 10.1016/S0378-1119(98)00130-9 contributor: fullname: Schweizer, HP – volume: 188 start-page: 8649 year: 2006 end-page: 8654 ident: B11 article-title: nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa publication-title: J Bacteriol doi: 10.1128/JB.01342-06 contributor: fullname: Poole, K – volume: 48 start-page: 1797 year: 2004 end-page: 1802 ident: B6 article-title: Clinical strains of Pseudomonas aeruginosa overproducing MexAB-OprM and MexXY efflux pumps simultaneously publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.48.5.1797-1802.2004 contributor: fullname: Plésiat, P – volume: 43 start-page: 2975 year: 1999 end-page: 2983 ident: B27 article-title: Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.43.12.2975 contributor: fullname: Stover, CK – volume: 57 start-page: 4449 year: 2013 end-page: 4462 ident: B45 article-title: KpnEF, a new member of the Klebsiella pneumoniae cell envelope stress response regulon, is an SMR-type efflux pump involved in broad-spectrum antimicrobial resistance publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.02284-12 contributor: fullname: Rajamohan, G – volume: 81 start-page: 600 year: 2013 end-page: 606 ident: B23 article-title: Diversity in structural consequences of mexZ mutations in Pseudomonas aeruginosa publication-title: Chem Biol Drug Des doi: 10.1111/cbdd.12104 contributor: fullname: Jahandideh, S – volume: 15 start-page: 7087 year: 2007 end-page: 7097 ident: B31 article-title: MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2007.07.039 contributor: fullname: Watkins, WJ – volume: 6 start-page: 377 year: 2015 ident: B3 article-title: RND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibition publication-title: Front Microbiol doi: 10.3389/fmicb.2015.00377 contributor: fullname: Ma, S – volume: 60 start-page: 2302 year: 2016 end-page: 2310 ident: B22 article-title: Amino acid substitutions account for most MexS alterations in clinical nfxC mutants of Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.02622-15 contributor: fullname: Llanes, C – volume: 159 start-page: 2058 year: 2013 end-page: 2073 ident: B17 article-title: Functional characterization of the NfxB repressor of the mexCD-oprJ multidrug efflux operon of Pseudomonas aeruginosa publication-title: Microbiology doi: 10.1099/mic.0.069286-0 contributor: fullname: Poole, K – volume: 279 start-page: 8761 year: 2004 end-page: 8768 ident: B49 article-title: CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa publication-title: J Biol Chem doi: 10.1074/jbc.M312080200 contributor: fullname: Köhler, T – volume: 75 start-page: 3902 year: 2007 end-page: 3912 ident: B72 article-title: The Pseudomonas aeruginosa secreted protein PA2934 decreases apical membrane expression of the cystic fibrosis transmembrane conductance regulator publication-title: Infect Immun doi: 10.1128/IAI.00338-07 contributor: fullname: O'Toole, GA – volume: 28 start-page: 337 year: 2015 end-page: 418 ident: B2 article-title: The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00117-14 contributor: fullname: Nikaido, H – volume: 7 year: 2012 ident: B46 article-title: Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044 publication-title: PLoS One doi: 10.1371/journal.pone.0033777 contributor: fullname: Rajamohan, G – volume: 14 start-page: 417 year: 2017 end-page: 419 ident: B63 article-title: Salmon provides fast and bias-aware quantification of transcript expression publication-title: Nat Methods doi: 10.1038/nmeth.4197 contributor: fullname: Kingsford, C – volume: 235 start-page: 386 year: 1994 end-page: 405 ident: B69 article-title: Analysis and construction of stable phenotypes in gram-negative bacteria with Tn5- and Tn10-derived minitransposons publication-title: Methods Enzymol doi: 10.1016/0076-6879(94)35157-0 contributor: fullname: Timmis, KN – volume: 15 start-page: 550 year: 2014 ident: B65 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 contributor: fullname: Anders, S – volume: 49 start-page: 565 year: 2005 end-page: 570 ident: B30 article-title: Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.49.2.565-570.2005 contributor: fullname: Wong-Beringer, A – volume: 67 start-page: 293 year: 2013 end-page: 299 ident: B28 article-title: Elongation factor P is dispensable in Escherichia coli and Pseudomonas aeruginosa publication-title: Curr Microbiol doi: 10.1007/s00284-013-0363-0 contributor: fullname: Dean, CR – volume: 192 start-page: 591 year: 1990 end-page: 599 ident: B50 article-title: Nitrous oxide reductase from denitrifying Pseudomonas stutzeri. Genes for copper-processing and properties of the deduced products, including a new member of the family of ATP/GTP-binding proteins publication-title: Eur J Biochem doi: 10.1111/j.1432-1033.1990.tb19265.x contributor: fullname: Braun, C – volume: 7 year: 2012 ident: B60 article-title: Identification of elongation factor G as the conserved cellular target of argyrin B publication-title: PLoS One doi: 10.1371/journal.pone.0042657 contributor: fullname: Dean, CR – volume: 52 start-page: 4478 year: 2008 end-page: 4482 ident: B58 article-title: MexCD-OprJ multidrug efflux system of Pseudomonas aeruginosa: involvement in chlorhexidine resistance and induction by membrane-damaging agents dependent upon the AlgU stress response sigma factor publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.01072-08 contributor: fullname: Poole, K – volume: 7 year: 2016 ident: B52 article-title: Regulation of Pseudomonas aeruginosa virulence by distinct iron sources publication-title: Genes (Basel) contributor: fullname: Oglesby-Sherrouse, AG – volume: 49 start-page: 999 year: 2005 end-page: 1002 ident: B37 article-title: Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa publication-title: Microbiol Immunol doi: 10.1111/j.1348-0421.2005.tb03696.x contributor: fullname: Tsuchiya, T – volume: 72 start-page: 40 year: 2016 end-page: 47 ident: B24 article-title: Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene publication-title: Thorax doi: 10.1136/thoraxjnl-2015-208027 contributor: fullname: Jain, M – volume: 2 start-page: 65 year: 2011 ident: B38 article-title: Pseudomonas aeruginosa: resistance to the max publication-title: Front Microbiol doi: 10.3389/fmicb.2011.00065 contributor: fullname: Poole, K – volume: 56 start-page: 5171 year: 2012 end-page: 5179 ident: B26 article-title: Reduced expression of the rplU-rpmA ribosomal protein operon in mexXY-expressing pan-aminoglycoside-resistant mutants of Pseudomonas aeruginosa publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.00846-12 contributor: fullname: Poole, K – year: 2008 ident: B67 publication-title: AMBER 10 ;University of California, San Francisco ;San Francisco, CA contributor: fullname: Kollman, PA – volume: 193 start-page: 3367 year: 2011 end-page: 3375 ident: B41 article-title: Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli publication-title: J Bacteriol doi: 10.1128/JB.01534-10 contributor: fullname: Raivio, TL – ident: e_1_3_3_50_2 doi: 10.1074/jbc.M312080200 – ident: e_1_3_3_29_2 doi: 10.1007/s00284-013-0363-0 – ident: e_1_3_3_49_2 doi: 10.1128/JB.00837-06 – ident: e_1_3_3_65_2 doi: 10.12688/f1000research.7563.2 – ident: e_1_3_3_42_2 doi: 10.1128/JB.01534-10 – ident: e_1_3_3_64_2 doi: 10.1038/nmeth.4197 – ident: e_1_3_3_22_2 doi: 10.1111/j.1758-2229.2010.00175.x – ident: e_1_3_3_67_2 doi: 10.1038/nmeth.3252 – ident: e_1_3_3_33_2 doi: 10.1038/nature12300 – ident: e_1_3_3_6_2 doi: 10.1128/JB.182.5.1410-1414.2000 – ident: e_1_3_3_18_2 doi: 10.1099/mic.0.069286-0 – ident: e_1_3_3_58_2 doi: 10.1128/AAC.01024-08 – ident: e_1_3_3_19_2 doi: 10.1016/S0924-8579(03)00009-8 – ident: e_1_3_3_14_2 doi: 10.1128/AAC.00253-09 – ident: e_1_3_3_9_2 doi: 10.1111/j.1365-2958.2004.04210.x – ident: e_1_3_3_16_2 doi: 10.1128/JB.188.5.1847-1855.2006 – ident: e_1_3_3_57_2 doi: 10.1038/srep40208 – ident: e_1_3_3_60_2 doi: 10.1016/j.mimet.2005.06.001 – ident: e_1_3_3_15_2 doi: 10.1128/JB.00073-09 – ident: e_1_3_3_43_2 doi: 10.1099/mic.0.26460-0 – ident: e_1_3_3_71_2 doi: 10.1006/plas.1994.1028 – ident: e_1_3_3_10_2 doi: 10.1155/2012/575193 – ident: e_1_3_3_11_2 doi: 10.1111/mmi.13346 – ident: e_1_3_3_4_2 doi: 10.3389/fmicb.2015.00377 – ident: e_1_3_3_12_2 doi: 10.1128/JB.01342-06 – ident: e_1_3_3_34_2 doi: 10.1016/j.bmcl.2018.01.006 – ident: e_1_3_3_41_2 doi: 10.1128/JB.187.5.1763-1772.2005 – ident: e_1_3_3_75_2 – ident: e_1_3_3_5_2 doi: 10.1093/nar/gkv1227 – ident: e_1_3_3_25_2 doi: 10.1136/thoraxjnl-2015-208027 – ident: e_1_3_3_62_2 doi: 10.1128/AAC.49.2.791-793.2005 – volume-title: AMBER 10 year: 2008 ident: e_1_3_3_68_2 contributor: fullname: Case DA – ident: e_1_3_3_24_2 doi: 10.1111/cbdd.12104 – ident: e_1_3_3_40_2 doi: 10.1128/JB.184.15.4168-4176.2002 – ident: e_1_3_3_56_2 doi: 10.1093/jac/dkr543 – ident: e_1_3_3_28_2 doi: 10.1128/AAC.43.12.2975 – ident: e_1_3_3_17_2 doi: 10.1099/mic.0.028993-0 – ident: e_1_3_3_63_2 doi: 10.1038/srep41114 – ident: e_1_3_3_3_2 doi: 10.1128/CMR.00117-14 – ident: e_1_3_3_47_2 doi: 10.1371/journal.pone.0033777 – ident: e_1_3_3_61_2 doi: 10.1371/journal.pone.0042657 – ident: e_1_3_3_48_2 doi: 10.1128/AAC.01252-10 – ident: e_1_3_3_73_2 doi: 10.1128/IAI.00338-07 – ident: e_1_3_3_55_2 doi: 10.1371/journal.pone.0034067 – ident: e_1_3_3_7_2 doi: 10.1128/AAC.48.5.1797-1802.2004 – ident: e_1_3_3_35_2 doi: 10.1128/AAC.05417-11 – ident: e_1_3_3_32_2 doi: 10.1016/j.bmc.2007.07.039 – ident: e_1_3_3_69_2 doi: 10.1128/AAC.36.9.1847 – ident: e_1_3_3_20_2 doi: 10.1046/j.1365-2958.1996.281397.x – ident: e_1_3_3_66_2 doi: 10.1186/s13059-014-0550-8 – ident: e_1_3_3_36_2 doi: 10.1021/acs.jmedchem.7b00377 – ident: e_1_3_3_21_2 doi: 10.1111/j.1574-6968.2010.02063.x – ident: e_1_3_3_39_2 doi: 10.3389/fmicb.2011.00065 – ident: e_1_3_3_31_2 doi: 10.1128/AAC.49.2.565-570.2005 – ident: e_1_3_3_37_2 doi: 10.1021/ja00170a016 – ident: e_1_3_3_45_2 doi: 10.1371/journal.ppat.1005932 – ident: e_1_3_3_30_2 doi: 10.1128/AAC.45.1.105-116.2001 – ident: e_1_3_3_2_2 doi: 10.1128/MMBR.67.4.593-656.2003 – ident: e_1_3_3_23_2 doi: 10.1128/AAC.02622-15 – ident: e_1_3_3_44_2 doi: 10.1128/JB.184.8.2319-2323.2002 – ident: e_1_3_3_13_2 doi: 10.1128/AAC.49.5.1782-1786.2005 – ident: e_1_3_3_51_2 doi: 10.1111/j.1432-1033.1990.tb19265.x – ident: e_1_3_3_8_2 doi: 10.1093/femsle/fnw166 – ident: e_1_3_3_70_2 doi: 10.1016/0076-6879(94)35157-0 – ident: e_1_3_3_26_2 doi: 10.1128/AAC.00704-06 – ident: e_1_3_3_46_2 doi: 10.1128/AAC.02284-12 – ident: e_1_3_3_52_2 doi: 10.1099/00221287-146-1-185 – ident: e_1_3_3_72_2 doi: 10.1016/S0378-1119(98)00130-9 – ident: e_1_3_3_74_2 – ident: e_1_3_3_27_2 doi: 10.1128/AAC.00846-12 – ident: e_1_3_3_38_2 doi: 10.1111/j.1348-0421.2005.tb03696.x – ident: e_1_3_3_53_2 doi: 10.3390/genes7120126 – ident: e_1_3_3_54_2 doi: 10.1128/JB.00095-07 – ident: e_1_3_3_59_2 doi: 10.1128/AAC.01072-08 |
| SSID | ssj0006590 |
| Score | 2.4161136 |
| Snippet | Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance.... Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance. Efflux... |
| SourceID | pubmedcentral proquest crossref asm2 pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| SubjectTerms | beta-Lactams beta-Lactams - pharmacology Imipenem - pharmacology Mechanisms of Resistance Microbial Sensitivity Tests Monobactams - pharmacology Piperidines Piperidines - pharmacology Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Quaternary Ammonium Compounds Quaternary Ammonium Compounds - pharmacology Tazobactam - pharmacology Thienamycins - pharmacology Transcriptome - genetics |
| Title | Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30420483 https://journals.asm.org/doi/10.1128/AAC.01718-18 https://search.proquest.com/docview/2132734992 https://pubmed.ncbi.nlm.nih.gov/PMC6355610 |
| Volume | 63 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ZbtNAFB1IJRAPIAhbWKoLgopKnaTxFpu3NEnVCtxaaSr1zRp7ZlpLyTiyYyn5LT6Eb-KOl5aAeOHV9iyWz93GZ84Q8klXxvahwan-4tSKuUeZY0c0wuggbUcaTqm2f3IxOLtyxxMtk2M3e2FK0n4cJV01X3RVclNyK5eLuNfwxHqBP9JBEsN-r0VamBs2JXrtfh27WljBWEot99Bq2O6G2xsOR12tD4N1kz6nT1fyWlEdvTHLF8Z2ZPor3fyTNflbGDp-Sp7U-SMMq3k-I_eFapMH1YmSmzZ56Nf_yttkL6hUqTcHMLvbZJUfwB4Ed3rVm-f3Hs9KNjh88cX6aJ8CUxwmUs6LNT3CGMfBF3p7cJIvchiXWaZeXwDMHKHSPq4dJqSyuYhtIUCgwKm6SSJ0GhmM-yb1MFpBoiDIRcFTNACWAxNZcZ2oNGcQDM_7X-FSxZpWqodggD4YpulcAObWOI-1f0bPl5mvO6mHwUF__qDfWbxiOD89d2yFHcxhKq712WRptoFRksVFol9xoaYX-zCqCPp6K37VK0zWNSNYvSCXx5PZ6ITWx0RQZlruiromG0g7lpFw4tjBaCsRG5bpmI5wDCsypCVthAk3Xc4ls5ln8NgxOR9gLcmFNzBfkh2VKvGagDQ4E8xkzLS5ZXPDs21Xiz9xLIJjzOw65KNGSljbeR6WJZThhoissERW2Hc75HODo3BZSYb847kPDchCtGn9o4YpkRZ5aPRNrTrkeUaHvKpAd9tTA9oOGWzB8fYBrRe-fQfNqNQNr83mzX-3fEseYb7oVaT1d2RnlRXiPWnlvNjFauT0225pib8APNc1Sg |
| link.rule.ids | 230,315,729,782,786,887,27933,27934,53800,53802 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3XbtswFGWbFB0PXe5y523RBg0QemhZ6ptjO3BQKxEcB-ibQIlUIsCmDMkC7N_qh_SbeqmR1C36kldRHAIP76AODwn5rDJjs6NxqmacGiF3KLPMgAboHSLTijSrUNsfn_VOftjDkZLJMeuzMAVpPwzilpwvWjK-LLiVy0XYrnlibc8dKCeJbr-9Q-7geu106iS9MsCWWW6toDelht0xar67Zrf7_UFLKcRg5qRu6lO5vNJUR3vMsoW27Zv-CTj_5k3-4YiOHt_wE56QR1XkCf2y-Cm5LWSD3C3votw0yD23-sveIHteqWe9OYDZ9fGs7AD2wLtWut48u_VwVvDI4asr1of7FJjkMIqieb6mh-gdObhCHSyOs0UGwyI-VTsTgDEnlKrJlamFJKofYl3wEGJwLC_jAM1NCsOuTh30cxBL8DKR8wSXDsuAiTS_iGWSMfD6p91vcC5DRUhVXTBA6w3TZC4Ao3Icx9o9oafL1FWNVN1gp79-0gkLVwzHp8aOtbCBOUzFhbrVLEk3MIjTMI_VJy7k9GwfBiW1Xx3iL1uF0briEsvn5PxoNBuMaXXBBGW6Ya-orbNeZIZRIKwwtNBPRzglhm7plrA0I9AiIzIx-eC6zXnETOZoPLR0znuYhXLh9PQXZFcmUrwiEGmcCaYzppvcMLnmmKatZKM4ps8hxoRN8kkhzK8sROYXyZdm-4hIv0Ck37Wb5EuNP39Zio38572PNTh9tAbqFw-TIskzX-vqSq_IcbQmeVmC9aqlGuxN0tuC8dULSml8uwTRWyiOV2h9feOaH8j98cyd-JPjk-9vyAOMOp2S-v6W7K7SXLwjOxnP3xfr-DdSF0nT |
| linkToPdf | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3ZbtNAFB1oERUPbGUL6wVBRaVOk4yX2LylWdSKJrXSVuLNmnhmWkvJOLJjKfktPoRv4o6XloJ4gVd7Nstn7mKfOZeQjyYzdlpMUPPGqR0Jn3LXmdIpegfluIq5hdr-4Wln_M3rD4xMzlWpr4K0H03jfT2b7-v4suBWLuZRs-aJNYNRzzhJdPvNhVDNDXIH92yL1Yl6ZYRdp_y8gh6V2l7LrjnvzGt2u719oxKD2ZOp1mfyeaOrjjaZZ3N20z_9EXT-zp38xRkNH_7HYzwiD6oIFLplk8fkttTb5G5Zk3K9TbZG1d_2bbITlLrW6z04uz6mle3BDgTXitfrJ7funxV8cvg8kquDXQpcCxgoNctX9AC9pICRNAeM42yeQb-IU80XCsDYE0r15MrkQqLqi9gXAoQaHOnLeIpmJ4V-26I--juINQSZzEWCW4hnwGWaX8Q6yTgE3ZP2FzjXkSGmmik4oBWHSTKTgNE5rmM1GtOTRToyg1TT4KQ_vtNjHi05rs-sHXvhADOYyAtT3SxJ19CL0yiPzSPO9eR0F3olxd8c5i9HhcGq4hTrp-R8ODjrHdKq0ATllu0tqWfxjnIiNZVuFLnorxW-FttyLVe6zJ4yZSsHkxBheUIo7nCfici1hOhgNiqk37GekU2daPmCgGKCS25xbjnCdgTzHccz8lEC0-gIY8MG-WBQFlaWIguLJIx5IaIyLFAZtr0G-VRjMFyUoiN_afe-BmiIVsH86uFaJnkWsrZldIt8nzXI8xKwVyPVgG-Qzg0oXzUwiuM37yCCC-XxCrEv_7nnO7IV9Ifh8dH46ytyD4NPv2TAvyabyzSXb8hGJvK3xVb-CaAqTFM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Target+%28MexB%29-+and+Efflux-Based+Mechanisms+Decreasing+the+Effectiveness+of+the+Efflux+Pump+Inhibitor+D13-9001+in+Pseudomonas+aeruginosa+PAO1%3A+Uncovering+a+New+Role+for+MexMN-OprM+in+Efflux+of+%CE%B2-Lactams+and+a+Novel+Regulatory+Circuit+%28MmnRS%29+Controlling+MexMN+Expression&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.au=Ranjitkar%2C+Srijan&rft.au=Jones%2C+Adriana+K&rft.au=Mostafavi%2C+Mina&rft.au=Zwirko%2C+Zachary&rft.date=2019-02-01&rft.eissn=1098-6596&rft.volume=63&rft.issue=2&rft_id=info:doi/10.1128%2FAAC.01718-18&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0066-4804&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0066-4804&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0066-4804&client=summon |