Highly Enantioselective Oxidation of Sulfides to Sulfoxides by a New Oxaziridinium Salt

Highly Enantioselective Oxidation of Sulfides to Sulfoxides by a New Oxaziridinium Salt

The new oxaziridinium salt 5 (R2 = TBDPS) is an effective reagent for the highly enantioselective oxidation of sulfides to sulfoxides with up to >99% ee and good yields. As such, it represents a new valuable nonmetallic alternative to the existing methods for asymmetric sulfoxidation.

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Bibliographic Details
Published in:Organic letters Vol. 9; no. 12; pp. 2265 - 2268
Main Authors: del Río, R. E, Wang, B, Achab, S, Bohé, L
Format: Journal Article
Language:English
Published: United States American Chemical Society 07-06-2007
Subjects:
Aziridines - chemical synthesis
Aziridines - chemistry
Chemical Sciences
Molecular Structure
Organic chemistry
Oxidation-Reduction
Stereoisomerism
Sulfides - chemistry
Sulfoxides - chemical synthesis
Sulfoxides - chemistry
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Description
Summary:The new oxaziridinium salt 5 (R2 = TBDPS) is an effective reagent for the highly enantioselective oxidation of sulfides to sulfoxides with up to >99% ee and good yields. As such, it represents a new valuable nonmetallic alternative to the existing methods for asymmetric sulfoxidation.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol0702573