Amine-Promoted Synthesis of Vinyl Aziridines
N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regioselective nucleophilic aziridination of α,β,γ,δ-unsaturated carbonyl compounds. The reaction is completely regioselective (>95: 5) for the α,β-alkene and completely diastereoselective, affording the trans-vinyl aziridine...
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Published in: | Journal of organic chemistry Vol. 75; no. 10; pp. 3499 - 3502 |
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Main Authors: | , , , |
Format: | Journal Article |
Language: | English |
Published: |
Washington, DC
American Chemical Society
21-05-2010
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Subjects: | |
Online Access: | Get full text |
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Summary: | N-Unsubstituted vinyl aziridines were synthesized via an amine-promoted regioselective nucleophilic aziridination of α,β,γ,δ-unsaturated carbonyl compounds. The reaction is completely regioselective (>95: 5) for the α,β-alkene and completely diastereoselective, affording the trans-vinyl aziridine in moderate-to-good yields. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/jo100407s |