Elucidating Substrate Promiscuity in the Human Cytochrome 3A4

The human cytochrome P450 enzymes (CYPs) are heme-protein monooxygenases, which catalyze oxidative reactions of a broad spectrum of substrates. Consequently, they play a critical role in the metabolism of xenobiotics, such as drugs and carcinogens, and the catabolism of endogenous lipophilic factors...

Full description

Bibliographic Details

Published in:	Journal of chemical information and modeling Vol. 54; no. 3; pp. 857 - 869
Main Authors:	Hayes, Christina, Ansbro, Daniel, Kontoyianni, Maria
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 24-03-2014
Subjects:	Binding Sites Biochemistry Cytochrome P-450 CYP3A - chemistry Cytochrome P-450 CYP3A - metabolism Drug Discovery Enzymes Humans Ligands Molecular Docking Simulation Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Substrate Specificity Substrates
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!