Protective Effect of Caffeic Acid against Alzheimer’s Disease Pathogenesis via Modulating Cerebral Insulin Signaling, β‑Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats

This study investigated the alleviative effect of caffeic acid (CA) on Alzheimer’s disease (AD) pathogenesis and associated mechanisms in high-fat (HF) diet-induced hyperinsulinemic rats. The results of a Morris water maze indicated that, by administrating CA (30 mg/kg b.w./day) for 30 weeks, the me...

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Bibliographic Details
Published in:	Journal of agricultural and food chemistry Vol. 67; no. 27; pp. 7684 - 7693
Main Authors:	Chang, Wenchang, Huang, Dawei, Lo, Y. Martin, Tee, Qinqiao, Kuo, Poling, Wu, James Swibea, Huang, Wenchung, Shen, Szuchuan
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 10-07-2019
Subjects:	cerebral carbohydrate metabolism caffeic acid hyperinsulinemic Alzheimer’s disease
Online Access:	Get full text
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