Cobalt-Catalyzed Chemoselective Reduction of N‑Heteroaryl Ketones with N,N‑Dimethylformamide as a Hydride Source

Cobalt-Catalyzed Chemoselective Reduction of N‑Heteroaryl Ketones with N,N‑Dimethylformamide as a Hydride Source

A method for chemoselective reduction of 2-pyridyl ketones and related N-heteroaryl compounds catalyzed by cobalt stearate using DMF as a hydride source is developed. The ketone substrate is activated by chelation with cobalt, which makes the present method highly chemoselective. A possible reaction...

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Bibliographic Details
Published in:Journal of organic chemistry Vol. 88; no. 13; pp. 8279 - 8285
Main Authors: Yu, Rurong, Hao, Feiyue, Zhang, Xinyu, Fang, Zhongbing, Jin, Zhengneng, Liu, Guyue, Dai, Guoliang, Wu, Jiashou
Format: Journal Article
Language:English
Published: United States American Chemical Society 07-07-2023
Subjects:
Catalysis
Cobalt - chemistry
Dimethylformamide
Ketones - chemistry
Molecular Structure
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Summary:A method for chemoselective reduction of 2-pyridyl ketones and related N-heteroaryl compounds catalyzed by cobalt stearate using DMF as a hydride source is developed. The ketone substrate is activated by chelation with cobalt, which makes the present method highly chemoselective. A possible reaction mechanism is proposed on the basis of control experiments.
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content type line 23
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c00283