Attack of zwitterionic ammonium thiolates on a distorted anilide as a model for the acylation of papain by amides. A simple demonstration of a bell-shaped pH/rate profile

Attack of zwitterionic ammonium thiolates on a distorted anilide as a model for the acylation of papain by amides. A simple demonstration of a bell-shaped pH/rate profile

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 114; no. 21; pp. 7983 - 7989
Main Authors: Keillor, J. W, Brown, R. S
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 01-10-1992
Subjects:
Chemistry
Exact sciences and technology
Kinetics and mechanisms
Organic chemistry
Reactivity and mechanisms
Intramolecular reaction
Five membered ring
Enzyme
Nitrogen heterocycle
Thiolate
Lactam
Papain
Enzyme model
Tricyclic compound
Medium effect
pH
Aromatic compound
Aminothiol
Rate constant
Acylation
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Description
Bibliography:istex:D1DE773C1DC4E605208779FBD9E90E53A3F0DC40
ark:/67375/TPS-5HC8C78Q-J
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00047a004