Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation an...

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Bibliographic Details
Published in:Organic process research & development Vol. 13; no. 6; pp. 1357 - 1363
Main Authors: Lawton, Simon, Steele, Gerry, Shering, Phil, Zhao, Lihua, Laird, Ian, Ni, Xiong-Wei
Format: Journal Article
Language:English
Published: American Chemical Society 20-11-2009
Online Access:Get full text
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Summary:In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process.
ISSN:1083-6160
1520-586X
DOI:10.1021/op900237x