Development of a Practical, Safe, and High-Yielding Process for the Preparation of Enantiomerically Pure trans-Cyclopropane Carboxylic Acid

Development of a Practical, Safe, and High-Yielding Process for the Preparation of Enantiomerically Pure trans-Cyclopropane Carboxylic Acid

A practical, safe, and high-yielding process for the cyclopropanation of a chiral epoxide has been developed using the inexpensive and nonhazardous reagents triethylphosphonoacetate and sodium tert-butoxide.

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Bibliographic Details
Published in:Organic process research & development Vol. 6; no. 5; pp. 618 - 620
Main Authors: Singh, Ambarish K, Rao, Meena N, Simpson, James H, Li, Wen-Sen, Thornton, John E, Kuehner, Daniel E, Kacsur, David J
Format: Journal Article
Language:English
Published: American Chemical Society 01-09-2002
Online Access:Get full text
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Description
Summary:A practical, safe, and high-yielding process for the cyclopropanation of a chiral epoxide has been developed using the inexpensive and nonhazardous reagents triethylphosphonoacetate and sodium tert-butoxide.
ISSN:1083-6160
1520-586X
DOI:10.1021/op0202033