Synthesis of meta-(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence

Synthesis of meta-(Indol-3-yl)phenols from Indoles and Cyclohexenone via Palladium(II)-Catalyzed Oxidative Heck Reaction and Dehydrogenative Aromatization in a One-Step Sequence

Facile construction of a meta-(indol-3-yl)­phenol framework with a wide substrate scope (a total of 25 compounds) via a palladium­(II)-catalyzed oxidative Heck reaction and dehydrogenative aromatization in a one-step sequence is reported. This methodology affords a novel route for the privileged str...

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Bibliographic Details
Published in:Organic letters Vol. 23; no. 19; pp. 7467 - 7471
Main Authors: Son, Seung Hwan, Shin, Jeong-Won, Won, Hyuck-Jae, Yoo, Hyung-Seok, Cho, Yang Yil, Kim, Soo Lim, Jang, Yoon Hu, Park, Boyoung Y, Kim, Nam-Jung
Format: Journal Article
Language:English
Published: American Chemical Society 01-10-2021
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Summary:Facile construction of a meta-(indol-3-yl)­phenol framework with a wide substrate scope (a total of 25 compounds) via a palladium­(II)-catalyzed oxidative Heck reaction and dehydrogenative aromatization in a one-step sequence is reported. This methodology affords a novel route for the privileged structures that are challenging to access via a direct link between indole and phenol, in a highly efficient and atom-economical manner.
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ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02679