Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4‑[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)‑3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)

Three unreported analogues of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogues of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254), are described...

Full description

Bibliographic Details

Published in:	Journal of medicinal chemistry Vol. 56; no. 21; pp. 8432 - 8454
Main Authors:	Jurutka, Peter W, Kaneko, Ichiro, Yang, Joanna, Bhogal, Jaskaran S, Swierski, Johnathon C, Tabacaru, Christa R, Montano, Luis A, Huynh, Chanh C, Jama, Rabia A, Mahelona, Ryan D, Sarnowski, Joseph T, Marcus, Lisa M, Quezada, Alexis, Lemming, Brittney, Tedesco, Maria A, Fischer, Audra J, Mohamed, Said A, Ziller, Joseph W, Ma, Ning, Gray, Geoffrey M, van der Vaart, Arjan, Marshall, Pamela A, Wagner, Carl E
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 14-11-2013
Subjects:	Coumaric Acids - chemical synthesis Coumaric Acids - chemistry Coumaric Acids - pharmacology Crystallography, X-Ray Dose-Response Relationship, Drug Humans Models, Molecular Molecular Structure Retinoid X Receptors - agonists Structure-Activity Relationship Tetrahydronaphthalenes - chemical synthesis Tetrahydronaphthalenes - chemistry Tetrahydronaphthalenes - pharmacology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!