Characteristics and Rates of Preterm Births During the COVID-19 Pandemic in Germany

• Published in: JAMA network open Vol. 7; no. 9; p. e2432438
• Main Authors: Staude, Birte, Misselwitz, Björn, Louwen, Frank, Rochwalsky, Ulrich, Oehmke, Frank, Köhler, Siegmund, Maier, Rolf F, Windhorst, Anita C, Ehrhardt, Harald
• Format: Journal Article
• Language: English
• Published: United States American Medical Association 03-09-2024
• Subjects: Adult; Cohort Studies; COVID-19 - epidemiology; COVID-19 - prevention & control; Female; Germany - epidemiology; Humans; Infant, Newborn; Obstetrics and Gynecology; Online Only; Original Investigation; Pandemics; Perinatal Care; Pregnancy; Premature Birth - epidemiology; Registries; SARS-CoV-2; Germany
• ISSN: 2574-3805; 2574-3805
• DOI: 10.1001/jamanetworkopen.2024.32438

Population-based analyses provided divergent data on the changes in preterm birth rates during the COVID-19 pandemic, and there is a gap of knowledge on the variations in birth characteristics.
To study changes in perinatal care, causes of preterm delivery, and very preterm (VPT; defined as <32 weeks' gestation) birth rates before and during the COVID-19 pandemic.
This population-level cohort study used data from the quality assurance registry, which covers all births in Hesse, Germany. Deliveries during the COVID-19 pandemic (2020) were compared with the corresponding grouped prepandemic time intervals (2017 to 2019). Analyses were executed between August 2023 and July 2024.
Analyses were directed to study differences in preterm births before and during 3 pandemic phases: first (March 14 to May 15, 2020) and second (October 19 to December 31, 2020) lockdowns and a period of less-vigorous restrictions between them (May 16 to October 18, 2020).
Outcomes of interest were variations in preterm birth rates in the context of baseline characteristics and causes of preterm births during vs before the first year of the COVID-19 pandemic.
From the total cohort of 184 827 births from 2017 to 2020, 719 stillbirths occurred and 184 108 infants were liveborn. Compared with the prepandemic period, medical care characteristics did not differ during the COVID-19 period. The odds of VPT births were lower during the pandemic period (odds ratio [OR], 0.87; 95% CI, 0.79-0.95) compared with the prepandemic period, with the greatest reduction observed during the second lockdown period (OR, 0.69; 95% CI, 0.55-0.84). Reduction in VPT births was attributed to fewer births in pregnancies among individuals with a history of serious disease (OR, 0.64; 95% CI, 0.50-0.83), pathologic cardiotocography (OR, 0.66; 95% CI, 0.53-0.82), and intrauterine infection (OR, 0.82; 95% CI, 0.72-0.92) while incidences of history of preterm birth, multiple pregnancies, serious or severe psychological distress, and preeclampsia, eclampsia, or hemolysis, elevated liver enzymes, and low platelet count syndrome as cause for preterm delivery remained unchanged.
In this population-based cohort study on the COVID-19 pandemic and preterm birth rates, the duration of exposure to mitigation measures during pregnancy was associated with accelerated reductions in preterm births. The findings of lower rates of baseline risks and causes of preterm deliveries support efforts to intensify health care prevention programs during pregnancy to reduce the preterm birth burden. These findings of this study put particular focus on hygiene measures to reduce the rate of deliveries for intrauterine infection and highlight the potential of expanding strategies to the different risks and causes of preterm delivery.