The structure of CC-1065, a potent antitumor agent and its binding to DNA

The structure of CC-1065, a potent antitumor agent and its binding to DNA

The crystal and molecular structure of a potent antitumor agent, CC-1065 (C sub(35)H sub(33)N sub(7)O sub(8)), has been determined, and circular dichoism studies have demonstrated a strong interaction between CC-1065 and DNA. The interaction between CC-1065 and a number of DNA polymers was studied b...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 103; no. 25; pp. 7629 - 7635
Main Authors: Chidester, C. G, Krueger, W. C, Mizsak, S. A, Duchamp, D. J, Martin, D. G
Format: Journal Article
Language:English
Published: American Chemical Society 01-12-1981
Online Access:Get full text
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Summary:The crystal and molecular structure of a potent antitumor agent, CC-1065 (C sub(35)H sub(33)N sub(7)O sub(8)), has been determined, and circular dichoism studies have demonstrated a strong interaction between CC-1065 and DNA. The interaction between CC-1065 and a number of DNA polymers was studied by circular dichroism. The CD effect requires double-stranded DNA and is strongest with poly(dA-dT):poly(dA-dT).
Bibliography:ark:/67375/TPS-ZSMQK6LG-4
istex:E4A05A11EAD0F8D8049F711DC0D71BDFE8D4178A
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0002-7863
1520-5126
DOI:10.1021/ja00415a035