A Straightforward Synthesis of Tetrameric Estrone-Based Macrocycles

A Straightforward Synthesis of Tetrameric Estrone-Based Macrocycles

A straightforward approach to macrocycles having four estrone-derived nuclei by the sequential Cu-catalyzed Huisgen azide−alkyne cycloaddition−Glaser−Eglington Cu homocoupling has been developed. Due to its efficiency and simplicity, this sequence is useful for application to different natural produ...

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Bibliographic Details
Published in:Organic letters Vol. 10; no. 16; pp. 3555 - 3558
Main Authors: Ramírez-López, Pedro, de la Torre, María C, Montenegro, Hector E, Asenjo, María, Sierra, Miguel A
Format: Journal Article
Language:English
Published: United States American Chemical Society 21-08-2008
Subjects:
Alkynes - chemistry
Azides - chemistry
Catalysis
Copper - chemistry
Cyclization
Estrone - analogs & derivatives
Estrone - chemical synthesis
Estrone - chemistry
Macrocyclic Compounds - chemical synthesis
Macrocyclic Compounds - chemistry
Molecular Structure
Stereoisomerism
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Summary:A straightforward approach to macrocycles having four estrone-derived nuclei by the sequential Cu-catalyzed Huisgen azide−alkyne cycloaddition−Glaser−Eglington Cu homocoupling has been developed. Due to its efficiency and simplicity, this sequence is useful for application to different natural product scaffolds.
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ISSN:1523-7060
1523-7052
DOI:10.1021/ol801313g