Understanding Enediyne−Protein Interactions:  Diyl Atom Transfer Results in Generation of Aminoacyl Radicals

Understanding Enediyne−Protein Interactions:  Diyl Atom Transfer Results in Generation of Aminoacyl Radicals

The origin of the protein modulating capacity of enediynes has been probed. A series of synthetic enediyne-derived diyls participated in atom transfer chemistry with a labeled amino acid. Subsequent experiments suggest that diyl radicals may modulate protein architecture via formation of captodative...

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Bibliographic Details
Published in:Organic letters Vol. 2; no. 6; pp. 811 - 813
Main Authors: Jones, Graham B, Plourde, Gary W, Wright, Justin M
Format: Journal Article
Language:English
Published: United States American Chemical Society 23-03-2000
Subjects:
Alkenes
Alkynes
Amino Acid Sequence
Amino Acids - chemistry
Apoproteins - chemistry
Molecular Sequence Data
Proteins - chemistry
Zinostatin
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Summary:The origin of the protein modulating capacity of enediynes has been probed. A series of synthetic enediyne-derived diyls participated in atom transfer chemistry with a labeled amino acid. Subsequent experiments suggest that diyl radicals may modulate protein architecture via formation of captodatively stabilized radicals.
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content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/ol0055566