Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia

Parathyroid hormone-related protein (PTHrP), which is secreted from a tumor, contributes to the progression of cachexia, a condition that is observed in half of all cancer patients. Although drug clearance was reported to decrease in patients with cancer cachexia, the details have not been clarified...

Full description

Saved in:

Bibliographic Details
Published in:	Molecular pharmaceutics Vol. 18; no. 12; pp. 4322 - 4330
Main Authors:	Fujita, Issei, Watanabe, Hiroshi, Ikegami, Komei, Imafuku, Tadashi, Ichimizu, Shota, Chikamatsu, Mayuko, Kobayashi, Kazuki, Tanaka, Ryusei, Yamada, Koichi, Maeda, Hitoshi, Maruyama, Toru
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 06-12-2021
Subjects:	Animals Cachexia - metabolism Caco-2 Cells Cytochrome P-450 CYP3A - genetics Hep G2 Cells Humans Liver - enzymology Male Midazolam - pharmacokinetics Neoplasms - complications NF-kappa B - physiology Parathyroid Hormone-Related Protein - physiology Protein Kinase C - physiology Rats Rats, Sprague-Dawley pharmacokinetics PTH receptor cytochrome P450 3A midazolam cancer cachexia parathyroid hormone-related protein
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!