Synthesis of Novel trans-4-(Substituted-benzamido)-3,4-dihydro-2H-benzo[b]pyran-3-ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 39; no. 23; pp. 4537 - 4539
Main Authors:	Chan, Wai N, Evans, John M, Hadley, Michael S, Herdon, Hugh J, Jerman, Jeffrey C, Morgan, Helen K. A, Stean, Tania O, Thompson, Mervyn, Upton, Neil, Vong, Antonio K
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 08-11-1996
Subjects:	Animals Anticonvulsants - chemical synthesis Anticonvulsants - metabolism Anticonvulsants. Antiepileptics. Antiparkinson agents Benzamides - chemical synthesis Benzamides - metabolism Benzopyrans - chemical synthesis Benzopyrans - metabolism Binding Sites Biological and medical sciences Medical sciences Mice Neuropharmacology Pharmacology. Drug treatments Radioligand Assay Rats Stereoisomerism Tritium Rat Central nervous system Anticonvulsant Oxygen heterocycle Stereoselectivity Structure activity relation Trans stereoisomer Bicyclic compound Aromatic compound Secondary alcohol Chemical synthesis Biological receptor Rodentia Oral administration In vitro In vivo Vertebrata Biological fixation Mammalia Mouse Animal Affinity Carboxamide Benzenic compound Brain (vertebrata)
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Bibliography:	This work was conducted in compliance with the Home Office (U.K.) Guidance on the operation of the Animals (Specific Procedures) Act 1986, and was reviewed and approved by the SB Procedures Review Panel. ark:/67375/TPS-FXRKDW2J-T istex:37545F0ECACD503556BAB2703424DCEE97810806 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm960535w