Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C–C Bond

Phosphonates often exhibit biological activities by mimicking the phosphates and carboxylates of biological molecules. The phosphonate phosphonothrixin (PTX), produced by the soil-dwelling bacterium Saccharothrix sp. ST-888, exhibits herbicidal activity. In this study, we propose a complete biosynth...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 144; no. 37; pp. 16715 - 16719
Main Authors:	Zhu, Yuxun, Shiraishi, Taro, Lin, Jianwen, Inaba, Keito, Ito, Atsuro, Ogura, Yusuke, Nishiyama, Makoto, Kuzuyama, Tomohisa
Format:	Journal Article
Language:	English
Published:	American Chemical Society 21-09-2022
Online Access:	Get full text
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