Pyroglutamination-Induced Changes in the Physicochemical Features of a CXCR4 Chemokine Peptide: Kinetic and Structural Analysis

We investigate the physicochemical effects of pyroglutamination on the QHALTSV-NH2 peptide, a segment of cytosolic helix 8 of the human C–X–C chemokine G-protein-coupled receptor type 4 (CXCR4). This modification, resulting from the spontaneous conversion of glutamine to pyroglutamic acid, has signi...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 62; no. 17; pp. 2530 - 2540
Main Authors:	Ferreira, Mariana M. L., de Souza, Sinval E. G., da Silva, Caroline C., Souza, Louise E. A., Bicev, Renata N., da Silva, Emerson R., Nakaie, Clovis R.
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 05-09-2023
Online Access:	Get full text
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