Enhancing Glioblastoma Immunotherapy with Integrated Chimeric Antigen Receptor T Cells through the Re-Education of Tumor-Associated Microglia and Macrophages

Glioblastoma (GBM) is an aggressive brain cancer that is highly resistant to treatment including chimeric antigen receptor (CAR)-T cells. Tumor-associated microglia and macrophages (TAMs) are major contributors to the immunosuppressive GBM microenvironment, which promotes tumor progression and treat...

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Bibliographic Details
Published in:	ACS nano Vol. 18; no. 17; pp. 11165 - 11182
Main Authors:	Zhu, Nianci, Chen, Sijia, Jin, Yu, Wang, Meng, Fang, Luyao, Xue, Lingjing, Hua, Dexiang, Zhang, Ziyao, Jia, Meng, Hao, Meixi, Zhang, Can
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 30-04-2024
Subjects:	Aminopyridines Animals Brain Neoplasms - drug therapy Brain Neoplasms - immunology Brain Neoplasms - pathology Brain Neoplasms - therapy Cell Line, Tumor Glioblastoma - drug therapy Glioblastoma - immunology Glioblastoma - pathology Glioblastoma - therapy Humans Immunotherapy Immunotherapy, Adoptive Liposomes - chemistry Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Microglia - drug effects Microglia - immunology Microglia - metabolism Pyrroles - chemistry Pyrroles - pharmacology Receptors, Chimeric Antigen - immunology Receptors, Chimeric Antigen - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tumor-Associated Macrophages - drug effects Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism blood−brain barrier cell−drug integrated technology glioblastoma re-educated TAMs CAR-T cells
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