PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis

Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored f...

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Bibliographic Details
Published in:	Accounts of chemical research Vol. 33; no. 6; pp. 336 - 345
Main Authors:	Helmchen, Günter, Pfaltz, Andreas
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-06-2000
Subjects:	Catalysis Ligands Molecular Conformation Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organophosphorus Compounds - chemical synthesis Organophosphorus Compounds - chemistry Oxazoles - chemical synthesis Oxazoles - chemistry Palladium - chemistry Phosphines - chemical synthesis Phosphines - chemistry Rubidium - chemistry Stereoisomerism
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Summary:	Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored for a specific application by variation of the oxazoline ring, the backbone, and the phosphine moiety.
Bibliography:	ark:/67375/TPS-FDMVM2Q6-N istex:CCF252F82E891051BAFF5D00FE8CC2BC7A7591B6 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0001-4842 1520-4898
DOI:	10.1021/ar9900865