Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity
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| Published in: | Journal of medicinal chemistry Vol. 12; no. 1; pp. 82 - 85 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
American Chemical Society
01-01-1969
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| Author | Baker, Bernard Randall Vermeulen, Nicolaas M. J |
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| Author_xml | – sequence: 1 givenname: Bernard Randall surname: Baker fullname: Baker, Bernard Randall – sequence: 2 givenname: Nicolaas M. J surname: Vermeulen fullname: Vermeulen, Nicolaas M. J |
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| SubjectTerms | Animals Benzene Derivatives Binding Sites Carbamates Chlorine Fluorides Folic Acid Antagonists Intestines - enzymology Isoenzymes Leukemia L1210 - enzymology Liver - enzymology Mice Pyrimidines - chemical synthesis Spleen - enzymology Sulfonic Acids - chemical synthesis |
| Title | Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity |
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