Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity

Irreversible enzyme inhibitors. CXXXVI. 2,4-Diamino-5-(3,4-dichlorophenyl)-6-[p-(m-fluorosulfonylbenzamido)phenoxymethyl]pyrimidine, an active-site-directed irreversible inhibitor of dihydrofolic reductase. Effect of structure on isozyme specificity

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry Vol. 12; no. 1; pp. 82 - 85
Main Authors: Baker, Bernard Randall, Vermeulen, Nicolaas M. J
Format: Journal Article
Language:English
Published: United States American Chemical Society 01-01-1969
Subjects:
Animals
Benzene Derivatives
Binding Sites
Carbamates
Chlorine
Fluorides
Folic Acid Antagonists
Intestines - enzymology
Isoenzymes
Leukemia L1210 - enzymology
Liver - enzymology
Mice
Pyrimidines - chemical synthesis
Spleen - enzymology
Sulfonic Acids - chemical synthesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Bibliography:istex:E38023E016FA8914319A17353F0F25BF8A59FD4A
ark:/67375/TPS-XBX54N3J-4
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00301a021