1-(Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinol esters. New potent antiamebic agents

A series of 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinols and certain O-acyl derivatives thereof have been prepared and shown to be potent antiamebic agents in the Entamoeba criceti infected hamster model. Compounds were compared with etichlordifene and diloxamide and one of them, 1-(dichloroa...

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Bibliographic Details
Published in:	Journal of medicinal chemistry Vol. 22; no. 5; pp. 599 - 601
Main Authors:	Bailey, Denis M, Mount, Eldridge M, Siggins, James, Carlson, John A, Yarinsky, Allen, Slighter, Ralph G
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 01-05-1979
Subjects:	Amebicides - chemical synthesis Animals Cecum - parasitology Cricetinae Dysentery, Amebic - drug therapy Dysentery, Amebic - parasitology Female Hydroxyquinolines - chemical synthesis Hydroxyquinolines - pharmacology Hydroxyquinolines - therapeutic use
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Summary:	A series of 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinols and certain O-acyl derivatives thereof have been prepared and shown to be potent antiamebic agents in the Entamoeba criceti infected hamster model. Compounds were compared with etichlordifene and diloxamide and one of them, 1-(dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydroquinoline (4), was selected for human trial.
Bibliography:	istex:316030607C4FED996B673C400A6ECC19A956CC7E ark:/67375/TPS-C7VBVPX3-V ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00191a031