Synaptotagmin I’s Intrinsically Disordered Region Interacts with Synaptic Vesicle Lipids and Exerts Allosteric Control over C2A

Synaptotagmin I (Syt I) is a vesicle-localized integral membrane protein that senses the calcium ion (Ca2+) influx to trigger fast synchronous release of neurotransmitter. How the cytosolic domains of Syt I allosterically communicate to propagate the Ca2+ binding signal throughout the protein is not...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 55; no. 21; pp. 2914 - 2926
Main Authors:	Fealey, Michael E, Mahling, Ryan, Rice, Anne M, Dunleavy, Katie, Kobany, Stephanie E. G, Lohese, K. Jean, Horn, Benjamin, Hinderliter, Anne
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 31-05-2016
Subjects:	Allosteric Regulation Amino Acid Sequence Binding Sites Calcium - metabolism Calorimetry, Differential Scanning Circular Dichroism Humans Lipids - chemistry Nuclear Magnetic Resonance, Biomolecular Protein Domains Synaptic Transmission Synaptic Vesicles - chemistry Synaptic Vesicles - metabolism Synaptotagmin I - chemistry Synaptotagmin I - metabolism
Online Access:	Get full text
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