Evidence for a Stereoselective Mechanism for Bitopic Activity by Extended-Length Antagonists of the D3 Dopamine Receptor

The D3 dopamine receptor (D3R) has been suggested as a drug target for the treatment of a number of neuropsychiatric disorders, including substance use disorders (SUD). Many D3R-selective antagonists are bivalent in nature in that they engage two distinct sites on the receptora primary pharmacophor...

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Bibliographic Details

Published in:	ACS chemical neuroscience Vol. 11; no. 20; pp. 3309 - 3320
Main Authors:	Moritz, Amy E, Bonifazi, Alessandro, Guerrero, Adrian M, Kumar, Vivek, Free, R. Benjamin, Lane, J. Robert, Verma, Ravi Kumar, Shi, Lei, Newman, Amy Hauck, Sibley, David R
Format:	Journal Article
Language:	English
Published:	American Chemical Society 21-10-2020
Subjects:	D3 receptor negative allosteric modulator noncompetitive antagonist Dopamine stereoselectivity bitopic
Online Access:	Get full text
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