The Biological Buffer Bicarbonate/CO2 Potentiates H2O2-Mediated Inactivation of Protein Tyrosine Phosphatases

Hydrogen peroxide is a cell signaling agent that inactivates protein tyrosine phosphatases (PTPs) via oxidation of their catalytic cysteine residue. PTPs are inactivated rapidly during H2O2-mediated cellular signal transduction processes, but, paradoxically, hydrogen peroxide is a rather sluggish PT...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 133; no. 40; pp. 15803 - 15805
Main Authors:	Zhou, Haiying, Singh, Harkewal, Parsons, Zachary D, Lewis, Sarah M, Bhattacharya, Sanjib, Seiner, Derrick R, LaButti, Jason N, Reilly, Thomas J, Tanner, John J, Gates, Kent S
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 12-10-2011
Subjects:	Bicarbonates - metabolism Buffers Carbon Dioxide - metabolism Enzyme Activation Humans Hydrogen Peroxide - metabolism Models, Molecular Oxidation-Reduction Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism
Online Access:	Get full text
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