Integrin Priming Dynamics: Mechanisms of Integrin Antagonist-Promoted αIIbβ3:PAC-1 Molecular Recognition

This investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the resting αIIbβ3 integrin, while macromolecules with similar integrin recognition motifs require an activated, or primed, receptor. Three structurally similar pharmaceutical integrin antagonists (eptif...

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Bibliographic Details

Published in:	Biochemistry (Easton) Vol. 48; no. 35; pp. 8355 - 8365
Main Authors:	Hantgan, Roy R, Stahle, Mary C
Format:	Journal Article
Language:	English
Published:	American Chemical Society 08-09-2009
Online Access:	Get full text
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