erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

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Bibliographic Details
Published in:Journal of medicinal chemistry Vol. 38; no. 19; pp. 3813 - 3820
Main Authors: Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, DiOrio, C I, Barbacci, E. G
Format: Journal Article
Language:English
Published: Washington, DC American Chemical Society 01-09-1995
Subjects:
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
Antineoplastic agent
Nitrogen heterocycle
Gene product
Lactam
Photoaffinity labelling
Organic carbamate
Macrocycle
Signal transduction
Structure activity relation
Established cell line
Bicyclic compound
Inhibition
Mechanism of action
Chemical synthesis
Protein-tyrosine kinase
Tumor cell
Enzyme
Transferases
Quinone
Rodentia
Malignant tumor
Gene expression
In vitro
In vivo
Vertebrata
Antibiotic
Chemotherapy
Chemical modification
Mammalia
Treatment
Mouse
Animal
Onc gene
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Description
Bibliography:istex:1CB39B8202C6E0FA813104212523E87E984D38B7
ark:/67375/TPS-38G7RS3D-L
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00019a011