Diastereo- and Enantioselective Dearomative Reductive Aryl-Fluoroalkenylation of Indoles by Nickel Catalysis

Diastereo- and Enantioselective Dearomative Reductive Aryl-Fluoroalkenylation of Indoles by Nickel Catalysis

Herein, we disclose a nickel-catalyzed dearomative reductive aryl-fluoroalkenylation of indoles by defluorinative coupling with gem-difluoroalkenes. The catalytic protocol affords a facile assembly of various monofluoroalkene-containing polycyclic fused indolines bearing two contiguous carbon stereo...

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Bibliographic Details
Published in:ACS catalysis Vol. 14; no. 9; pp. 6432 - 6439
Main Authors: Huang, Xinmiao, Ou, Min, Hong, Lixin, Qin, Wenjie, Ma, Yuanhong
Format: Journal Article
Language:English
Published: American Chemical Society 03-05-2024
Subjects:
indoles
asymmetric dearomatization
gem-difluoroalkenes
reductive coupling
nickel catalysis
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Summary:Herein, we disclose a nickel-catalyzed dearomative reductive aryl-fluoroalkenylation of indoles by defluorinative coupling with gem-difluoroalkenes. The catalytic protocol affords a facile assembly of various monofluoroalkene-containing polycyclic fused indolines bearing two contiguous carbon stereocenters in high diastereo- and enantioselectivities with tolerance of diverse functional groups.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.4c00560