H4octapa: An Acyclic Chelator for 111In Radiopharmaceuticals

This preliminary investigation of the octadentate acyclic chelator H4octapa (N4O4) with 111In/115In3+ has demonstrated it to be an improvement on the shortcomings of the current industry “gold standards” DOTA (N4O4) and DTPA (N3O5). The ability of H4octapa to radiolabel quantitatively 111InCl3 at am...

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Bibliographic Details
Published in:	Journal of the American Chemical Society Vol. 134; no. 20; pp. 8670 - 8683
Main Authors:	Price, Eric W, Cawthray, Jacqueline F, Bailey, Gwendolyn A, Ferreira, Cara L, Boros, Eszter, Adam, Michael J, Orvig, Chris
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 23-05-2012
Subjects:	Animals Chelating Agents - chemistry Chelating Agents - pharmacokinetics Female Heterocyclic Compounds, 1-Ring - chemistry Heterocyclic Compounds, 1-Ring - pharmacokinetics Indium Radioisotopes - chemistry Indium Radioisotopes - pharmacokinetics Mice Models, Molecular Pentetic Acid - chemistry Pentetic Acid - pharmacokinetics Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Thermodynamics Tissue Distribution
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