68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis

68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis

Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68Ga-NODAGA-indole, that can noninvasively detect and...

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Published in:Journal of the American Chemical Society Vol. 141; no. 14; pp. 5593 - 5596
Main Authors: Wahsner, Jessica, Désogère, Pauline, Abston, Eric, Graham-O’Regan, Katherine A, Wang, Junfeng, Rotile, Nicholas J, Schirmer, Markus D, Santos Ferreira, Diêgo Dos, Sui, Jingyi, Fuchs, Bryan C, Lanuti, Michael, Caravan, Peter
Format: Journal Article
Language:English
Published: American Chemical Society 10-04-2019
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Abstract Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated (R 2 = 0.98) with the concentration of lung allysine.
AbstractList Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated (R 2 = 0.98) with the concentration of lung allysine.
Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography (PET) probe, 68 Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68 Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated (R 2 = 0.98) with the concentration of lung allysine.
Author Caravan, Peter
Lanuti, Michael
Fuchs, Bryan C
Sui, Jingyi
Wang, Junfeng
Santos Ferreira, Diêgo Dos
Désogère, Pauline
Rotile, Nicholas J
Wahsner, Jessica
Abston, Eric
Schirmer, Markus D
Graham-O’Regan, Katherine A
AuthorAffiliation MGH & HMS
Division of Surgical Oncology
Division of Thoracic Surgery
Stroke Division
Department of Radiology
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– name: 1 The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital (MGH) & Harvard Medical School (HMS), Charlestown, MA 02129, USA
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Title 68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis
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