Synthesis of Bis-Macrocyclic HCV Protease Inhibitor MK-6325 via Intramolecular sp 2–sp 3 Suzuki–Miyaura Coupling and Ring Closing Metathesis

A practical asymmetric synthesis of the complex fused bis-macrocyclic HCV protease inhibitor MK-6325 (1) is described. Through the combination of a high yielding and low catalyst loading ring-closing metathesis (RCM) to forge the 15-membered macrocycle with an intramolecular sp 2–sp 3 Suzuki–Miyaura...

Full description

Bibliographic Details

Published in:	Organic letters Vol. 17; no. 6; pp. 1533 - 1536
Main Authors:	Li, Hongmei, Scott, Jeremy P, Chen, Cheng-yi, Journet, Michel, Belyk, Kevin, Balsells, Jaume, Kosjek, Birgit, Baxter, Carl A, Stewart, Gavin W, Wise, Christopher, Alam, Mahbub, Song, Zhiguo Jake, Tan, Lushi
Format:	Journal Article
Language:	English
Published:	American Chemical Society 20-03-2015
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!