Synthetic Route Design of AZD4635, an A2AR Antagonist

Synthetic Route Design of AZD4635, an A2AR Antagonist

The AstraZeneca approach to synthetic Route Design is exemplified through our AZD4635 chemical development program. The identification of possible new route concepts is presented, as well as their subsequent prioritization for practical exploration based on project objectives. Selected ideas were te...

Full description

Saved in:
Bibliographic Details
Published in:Organic process research & development Vol. 23; no. 7; pp. 1407 - 1419
Main Authors: Littleson, Mairi M, Campbell, Andrew D, Clarke, Adam, Dow, Mark, Ensor, Gareth, Evans, Matthew C, Herring, Adam, Jackson, Bethany A, Jackson, Lucinda V, Karlsson, Staffan, Klauber, David J, Legg, Danny H, Leslie, Kevin W, Moravčík, Štefan, Parsons, Chris D, Ronson, Thomas O, Meadows, Rebecca E
Format: Journal Article
Language:English
Published: American Chemical Society 19-07-2019
Subjects:
route design
SELECT criteria
process design
route decision
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The AstraZeneca approach to synthetic Route Design is exemplified through our AZD4635 chemical development program. The identification of possible new route concepts is presented, as well as their subsequent prioritization for practical exploration based on project objectives. Selected ideas were tested to demonstrate proof of concept for the bond formation strategy and, where successful, were fed into a decision tool based on key SELECTion principles.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.9b00171