Latifolians A and B, Novel JNK3 Kinase Inhibitors from the Papua New Guinean Plant Gnetum l atifolium

Latifolians A and B, Novel JNK3 Kinase Inhibitors from the Papua New Guinean Plant Gnetum l atifolium

As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR an...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) Vol. 68; no. 7; pp. 1080 - 1082
Main Authors: Rochfort, Simone J, Towerzey, Leanne, Carroll, Anthony, King, Gordon, Michael, Adam, Pierens, Greg, Rali, Topul, Redburn, Joanne, Whitmore, Jaqueline, Quinn, Ronald J
Format: Journal Article
Language:English
Published: American Chemical Society 22-07-2005
Online Access:Get full text
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Summary:As part of our search for natural products active against the JNK3 kinase, two novel, charged benzylisoquinolines, latifolian A (1) and latifolian B (2), were isolated from the stem bark of the Papua New Guinean vine Gnetum latifolium. The planar structures were determined through detailed 2D NMR analysis. The relative configurations were assigned after examination of the ROESY data and through detailed molecular modeling studies.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049616i