A Novel Class of Zinc-Binding Inhibitors for the Phosphatidylcholine-Preferring Phospholipase C from Bacillus c ereus

The phospholipase C (PLC) isozymes catalyze the hydrolysis of phospholipids to provide diacylglycerol (DAG) and a phosphorylated headgroup. Because DAG has been implicated in cellular signal transduction cascades in mammalian systems, there has been considerable interest in the development of inhibi...

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Bibliographic Details

Published in:	Journal of organic chemistry Vol. 65; no. 15; pp. 4509 - 4514
Main Authors:	Martin, Stephen F, Follows, Bruce C, Hergenrother, Paul J, Franklin, Christopher L
Format:	Journal Article
Language:	English
Published:	American Chemical Society 28-07-2000
Online Access:	Get full text
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