Search Results - by The American Society of Hematology

Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study by Curtis, Rochelle E., Metayer, Catherine, Rizzo, J.Douglas, Socié, Gérard, Sobocinski, Kathleen A., Flowers, Mary E.D., Travis, William D., Travis, Lois B., Horowitz, Mary M., Deeg, H.Joachim

“…Previous studies of recipients of hematopoietic stem-cell transplants suggest that graft-versus-host disease (GVHD) and its therapy may increase the risk for…”
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Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001 by Morton, Lindsay M., Wang, Sophia S., Devesa, Susan S., Hartge, Patricia, Weisenburger, Dennis D., Linet, Martha S.

“…Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future…”
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Current concepts in the pathophysiology and treatment of aplastic anemia by Young, Neal S., Calado, Rodrigo T., Scheinberg, Phillip

“…Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Almost universally fatal just a few decades ago,…”
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The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells by Guzman, Monica L., Rossi, Randall M., Karnischky, Lilliana, Li, Xiaojie, Peterson, Derick R., Howard, Dianna S., Jordan, Craig T.

“…Recent studies have described malignant stem cells as central to the initiation, growth, and potential relapse of acute and chronic myelogenous leukemia (AML…”
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The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? by Beutler, Ernest, Waalen, Jill

“…The diagnosis of anemia is an important aspect of the practice of hematology. The first step is to decide whether the patient is, in fact, anemic. Unless…”
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Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion by Bryceson, Yenan T., March, Michael E., Ljunggren, Hans-Gustaf, Long, Eric O.

“…Freshly isolated, resting natural killer (NK) cells are generally less lytic against target cells than in vitro interleukin 2 (IL-2)-activated NK cells. To…”
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A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation by Braun, Deborah, Longman, Randy S., Albert, Matthew L.

“…Prostaglandins, a family of lipidic molecules released during inflammation, display immunomodulatory properties in several models. One use includes exposure of…”
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Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation by Hanamura, Ichiro, Stewart, James P., Huang, Yongsheng, Zhan, Fenghuang, Santra, Madhumita, Sawyer, Jeffrey R., Hollmig, Klaus, Zangarri, Maurizio, Pineda-Roman, Mauricio, van Rhee, Frits, Cavallo, Federica, Burington, Bart, Crowley, John, Tricot, Guido, Barlogie, Bart, Shaughnessy, John D.

“…Using fluorescence in situ hybridization we investigated amplification of chromosome band 1q21 (Amp1q21) in more than 500 untreated patients with monoclonal…”
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Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma by Bergsagel, P. Leif, Kuehl, W. Michael, Zhan, Fenghuang, Sawyer, Jeffrey, Barlogie, Bart, Shaughnessy, John

“…Two oncogenic pathways have been hypothesized for multiple myeloma (MM) and premalignant monoclonal gammopathy of undetermined significance (MGUS) tumors: a…”
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Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells by Imai, Chihaya, Iwamoto, Shotaro, Campana, Dario

“…Natural killer (NK) cells hold promise for improving the therapeutic potential of allogeneic hematopoietic transplantation, but their effectiveness is limited…”
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Identification and characterization of circulating human transitional B cells by Sims, Gary P., Ettinger, Rachel, Shirota, Yuko, Yarboro, Cheryl H., Illei, Gabor G., Lipsky, Peter E.

“…Murine B-cell development begins in bone marrow and results in the generation of immature transitional B cells that transit to the spleen to complete their…”
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A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules by Fernandez, Nadine C., Treiner, Emmanuel, Vance, Russell E., Jamieson, Amanda M., Lemieux, Suzanne, Raulet, David H.

“…It is widely believed that self-tolerance of natural killer (NK) cells occurs because each NK cell expresses at least one inhibitory receptor specific for a…”
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Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study by Fraser, Christopher J., Bhatia, Smita, Ness, Kirsten, Carter, Andrea, Francisco, Liton, Arora, Mukta, Parker, Pablo, Forman, Stephen, Weisdorf, Daniel, Gurney, James G., Baker, K. Scott

“…The aim of this study was to understand the impact of chronic graft-versus-host disease (cGVHD) on the overall health status of hematopoietic cell…”
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Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients by Slichter, Sherrill J., Davis, Kathryn, Enright, Helen, Braine, Hayden, Gernsheimer, Terry, Kao, Kuo-Jang, Kickler, Thomas, Lee, Edward, McFarland, Janice, McCullough, Jeffrey, Rodey, Glenn, Schiffer, Charles A., Woodson, Robert

“…A variety of patientand product-related factors influenced the outcome of 6379 transfusions given to 533 patients in the Trial to Reduce Alloimmunization to…”
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Total body irradiation selectively induces murine hematopoietic stem cell senescence by Wang, Yong, Schulte, Bradley A., LaRue, Amanda C., Ogawa, Makio, Zhou, Daohong

“…Exposure to ionizing radiation (IR) and certain chemotherapeutic agents not only causes acute bone marrow (BM) suppression but also leads to long-term residual…”
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Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia by Taussig, David C., Pearce, Daniel J., Simpson, Catherine, Rohatiner, Ama Z., Lister, T. Andrew, Kelly, Gavin, Luongo, Jennifer L., Danet-Desnoyers, Gwenn-aël H., Bonnet, Dominique

“…Human hematopoietic stem cells (HSCs) are generally regarded as being devoid of the markers expressed by differentiated blood cells, the lineage-specific…”
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TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens by Peyssonnaux, Carole, Zinkernagel, Annelies S., Datta, Vivekanand, Lauth, Xavier, Johnson, Randall S., Nizet, Victor

“…Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis. Here we demonstrate the…”
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Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function by Williams, Cassin Kimmel, Li, Ji-Liang, Murga, Matilde, Harris, Adrian L., Tosato, Giovanna

“…Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and…”
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CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain by Courret, Nathalie, Darche, Sylvie, Sonigo, Pierre, Milon, Geneviève, Buzoni-Gâtel, Dominique, Tardieux, Isabelle

“…The protozoan parasite Toxoplasma gondii enters hosts through the intestinal mucosa and colonizes distant tissues such as the brain, where its progeny persists…”
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Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling by Fu, Kai, Weisenburger, Dennis D., Greiner, Timothy C., Dave, Sandeep, Wright, George, Rosenwald, Andreas, Chiorazzi, Michael, Iqbal, Javeed, Gesk, Stefan, Siebert, Reiner, De Jong, Daphne, Jaffe, Elaine S., Wilson, Wyndham H., Delabie, Jan, Ott, German, Dave, Bhavana J., Sanger, Warren G., Smith, Lynette M., Rimsza, Lisa, Braziel, Rita M., Müller-Hermelink, H. Konrad, Campo, Elias, Gascoyne, Randy D., Staudt, Louis M., Chan, Wing C.

“…Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been…”
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