Search Results - Zuniga, Edison S.

The future for early-stage tuberculosis drug discovery by Zuniga, Edison S, Early, Julie, Parish, Tanya

“…There is an urgent need for new and better drugs to treat tuberculosis due to lengthy and complex treatment regimens and a rising problem of drug resistance…”
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Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents by Kesicki, Edward A, Bailey, Mai A, Ovechkina, Yulia, Early, Julie V, Alling, Torey, Bowman, Julie, Zuniga, Edison S, Dalai, Suryakanta, Kumar, Naresh, Masquelin, Thierry, Hipskind, Philip A, Odingo, Joshua O, Parish, Tanya

“…The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity…”
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Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis by Wescott, Heather H, Zuniga, Edison S, Bajpai, Anumita, Trujillo, Carolina, Ehrt, Sabine, Schnappinger, Dirk, Roberts, David M, Parish, Tanya

“…Tuberculosis is a massive global burden and is increasingly resistant to first- and second-line drugs. There is an acute need for new anti-mycobacterial drugs…”
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Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24 by Botchkina, Galina I, Zuniga, Edison S, Rowehl, Rebecca H, Park, Rosa, Bhalla, Rahuldev, Bialkowska, Agnieszka B, Johnson, Francis, Golub, Lorne M, Zhang, Yu, Ojima, Iwao, Shroyer, Kenneth R

“…Prostate cancer is the second leading cause of cancer death among men. Multiple evidence suggests that a population of tumor-initiating, or cancer stem cells…”
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The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents by Zuniga, Edison S., Korkegian, Aaron, Mullen, Steven, Hembre, Erik J., Ornstein, Paul L., Cortez, Guillermo, Biswas, Kallolmay, Kumar, Naresh, Cramer, Jeffrey, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya

“…[Display omitted] We identified a di-substituted triazolopyrimidine with anti-tubercular activity against Mycobacterium tuberculosis. Three segments of the…”
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New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells by Botchkina, Galina I, Zuniga, Edison S, Das, Manisha, Wang, Yuan, Wang, Hichao, Zhu, Shu, Savitt, Anne G, Rowehl, Rebecca A, Leyfman, Yan, Ju, Jingfang, Shroyer, Kenneth, Ojima, Iwao

“…Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs)…”
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Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase by Melief, Eduard, Bonnett, Shilah A, Zuniga, Edison S, Parish, Tanya

“…The diaminoquinazoline series has good potency against Resistant isolates have mutations in Rv3161c, a putative dioxygenase. We carried out metabolite analysis…”
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Design, Synthesis, and Biological Evaluation of Theranostic Vitamin–Linker–Taxoid Conjugates by Vineberg, Jacob G, Wang, Tao, Zuniga, Edison S, Ojima, Iwao

“…Novel tumor-targeting theranostic conjugates 1 and 2, bearing either a fluorine-labeled prosthetic as a potential 18F-PET radiotracer (1) or a fluorescence…”
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Design, Synthesis, and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid–Camptothecin Combination Chemotherapy by Vineberg, Jacob G, Zuniga, Edison S, Kamath, Anushree, Chen, Ying-Jen, Seitz, Joshua D, Ojima, Iwao

“…Novel tumor-targeting dual-warhead conjugates, 2 (DW-1) and 3 (DW-2), which consist of a next-generation taxoid, 1 (SB-T-1214), and camptothecin as two…”
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Fluorine-containing taxoid anticancer agents and their tumor-targeted drug delivery by Seitz, Joshua, Vineberg, Jacob G., Zuniga, Edison S., Ojima, Iwao

“…This account presents our recent progress, in perspective, on the strategic incorporation of fluorine(s) for the development of taxoid-based tumor-targeted…”
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Tumor-targeting drug delivery of new-generation taxoids by Ojima, Iwao, Zuniga, Edison S, Berger, William T, Seitz, Joshua D

“…A long-standing problem of conventional cancer chemotherapy is the lack of tumor specificity. Tumor-targeting drug-delivery systems have been explored to…”
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Targeted and armed oncolytic adenovirus via chemoselective modification by Banerjee, Partha S., Zuniga, Edison S., Ojima, Iwao, Carrico, Isaac S.

“…Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When…”
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Design, synthesis and biological evaluation of new-generation taxoid-based tumor-targeting by Zuniga, Edison S

“…Over the past decades, chemotherapy has transitioned to an age of "targeted therapy." The development of Gleevec (Novartis) and Tarceva (Genentech and OSI…”
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Application of a correct reading on the inadmissibility of the claim by Granizo Montalvo, César, Guerrero Zuñiga, Edison, Arcos Morales, Jorge, Frías Raza, Sergio

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Application of a correct reading on the inadmissibility of the claim by Granizo Montalvo, César, Guerrero Zuñiga, Edison, Arcos Morales, Jorge, Frías Raza, Sergio

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Superovulation strategies for 6 commonly used mouse strains by Luo, Charlie, Zuniga, Juliana, Edison, Earnessa, Palla, Shana, Dong, Wenli, Parker-Thornburg, Jan

“…We examined different weight ranges and hormone dosages to determine superovulation protocols for 6 mouse strains commonly used in genetic engineering:…”
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Psychometric Properties of the Recovery Experiences Questionnaire in Peruvian Teachers of Regular Basic Education by Carranza Esteban, Renzo Felipe, Mamani-Benito, Oscar, Zúñiga, Dámaris Quinteros, Turpo Chaparro, Josué Edison, Romero, Abel Apaza, Murillo, Walter

“…The objective of this study was to analyze the psychometric properties of the recovery experiences questionnaire in Peruvian teachers of regular basic…”
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Exploitation and potential use of Phytelephasaequatorialis Spruce as a non-timber forest product by Alfredo Jiménez González, Edison Eduardo Saltos Arteaga, Marcos Pedro Ramos Rodríguez, Cristóbal Gonzalo Cantos Cevallos, Mónica Virginia Tapia Zúñiga

“…In the Andil and Caña Brava communities, adjacent to the estate of the Southern State University of Manabí located on the Jipijapa-Noboa road, a study was…”
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HMDB: a knowledgebase for the human metabolome by Wishart, David S, Knox, Craig, Guo, An Chi, Eisner, Roman, Young, Nelson, Gautam, Bijaya, Hau, David D, Psychogios, Nick, Dong, Edison, Bouatra, Souhaila, Mandal, Rupasri, Sinelnikov, Igor, Xia, Jianguo, Jia, Leslie, Cruz, Joseph A, Lim, Emilia, Sobsey, Constance A, Shrivastava, Savita, Huang, Paul, Liu, Philip, Fang, Lydia, Peng, Jun, Fradette, Ryan, Cheng, Dean, Tzur, Dan, Clements, Melisa, Lewis, Avalyn, De Souza, Andrea, Zuniga, Azaret, Dawe, Margot, Xiong, Yeping, Clive, Derrick, Greiner, Russ, Nazyrova, Alsu, Shaykhutdinov, Rustem, Li, Liang, Vogel, Hans J, Forsythe, Ian

“…The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical…”
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Molecular features of influenza A (H1N1)pdm09 prevalent in Mexico during winter seasons 2012-2014 by Arellano-Llamas, Rocío, Alfaro-Ruiz, Luis, Arriaga Canon, Cristian, Imaz Rosshandler, Ivan, Cruz-Lagunas, Alfredo, Zúñiga, Joaquín, Rebollar Vega, Rosa, Wong, Christopher W, Maurer-Stroh, Sebastian, Romero Córdoba, Sandra, Liu, Edison T, Hidalgo-Miranda, Alfredo, Vázquez-Pérez, Joel A

“…Since the emergence of the pandemic H1N1pdm09 virus in Mexico and California, biannual increases in the number of cases have been detected in Mexico. As…”
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