Search Results - VanWert, Adam L

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion by Misiewicz, Bryan, Mencer, Donald, Terzaghi, William, VanWert, Adam L

“…Oxalate is a divalent organic anion that affects many biological and commercial processes. It is derived from plant sources, such as spinach, rhubarb, tea,…”
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Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology by VanWert, Adam L., Gionfriddo, Michael R., Sweet, Douglas H.

“…Our understanding of the mechanisms behind inter‐ and intra‐patient variability in drug response is inadequate. Advances in the cytochrome P450 drug…”
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Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review by Bommareddy, Ajay, Brozena, Sarah, Steigerwalt, James, Landis, Terra, Hughes, Sarah, Mabry, Erica, Knopp, Aaron, VanWert, Adam L., Dwivedi, Chandradhar

“…Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its wide range of health benefits have been attributed to the…”
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Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway by Bommareddy, Ajay, Knapp, Kacey, Nemeth, Abigail, Steigerwalt, James, Landis, Terra, Vanwert, Adam L, Gorijavolu, Harsha P, Dwivedi, Chandradhar

“…Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms…”
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α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation by Bommareddy, Ajay, Rule, Brittny, VanWert, Adam L., Santha, Sreevidya, Dwivedi, Chandradhar

“…α-Santalol, a major component of sandalwood oil showed anti-cancer activity in prostate cancer cells by inducing apoptosis and activation of caspase-3…”
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Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (Slc22a8) Knockout Mice: A Gender Specific Impact of Reduced Folates by VanWert, Adam L., Sweet, Douglas H.

“…Purpose To elucidate the role of the renal basolateral transporter, Oat3, in the disposition of methotrexate. Materials and Methods Chinese hamster ovary cells…”
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Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G by Vanwert, Adam L, Bailey, Rachel M, Sweet, Douglas H

“…The interaction of renal basolateral organic anion transporter 3 (Oat3) with commonly used pharmacotherapeutics (e.g., NSAIDs, beta-lactams, and methotrexate)…”
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Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin by Vanwert, Adam L, Srimaroeng, Chutima, Sweet, Douglas H

“…Carboxyfluoroquinolones, such as ciprofloxacin, are used for the treatment of numerous infectious diseases. Renal secretion is a major determinant of their…”
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Additive toxic effect of deltamethrin and cadmium on hepatic, hematological, and immunological parameters in mice by Rehman, Hasibur, Aziz, Al Thbiani, Saggu, Shalini, VanWert, Adam L, Zidan, Nahla, Saggu, Sundeep

“…Exposure to natural and man-made environmental toxins concurrently can pose a greater threat to multiple organs. In the present work, we investigated…”
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A Copper(II) Macrocycle Complex for Sensing Biologically Relevant Organic Anions in a Competitive Fluorescence Assay: Oxalate Sensor or Urate Sensor? by Hontz, David, Hensley, Jayden, Hiryak, Kayla, Lee, Jennifer, Luchetta, Jared, Torsiello, Maria, Venditto, Michael, Lucent, Del, Terzaghi, William, Mencer, Donald, Bommareddy, Ajay, VanWert, Adam L

“…Fluorescence sensing of oxalate has garnered some attention in the past two decades as a result of this anion’s prominence and impact on society. Previous work…”
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Simultaneous expression of ClopHensor and SLC26A3 reveals the nature of endogenous oxalate transport in CHO cells by Wasiluk, Teresa, Roueinfar, Mina, Hiryak, Kayla, Torsiello, Maria, Miner, Alexander, Lee, Jennifer, Venditto, Michael, Terzaghi, William, Lucent, Del, VanWert, Adam L

“…ClopHensor, a fluorescent fusion protein, is a dual function biosensor that has been utilized as a tool for the simultaneous measurement of intracellular…”
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Chemoprevention of prostate cancer by major dietary phytochemicals by Bommareddy, Ajay, Eggleston, William, Prelewicz, Stacy, Antal, Andrea, Witczak, Zbigniew, McCune, Dan F, Vanwert, Adam L

“…Prostate cancer continues to be one of the most commonly diagnosed diseases and the second leading cause of cancer-related deaths among men in the United…”
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Survivin Down-regulation by α-Santalol Is Not Mediated Through PI3K-AKT Pathway in Human Breast Cancer Cells by Bommareddy, Ajay, Crisamore, Karryn, Fillman, Sarah, Brozena, Sarah, Steigerwalt, James, Landis, Terra, Vanwert, Adam L, Dwivedi, Chandradhar

“…α-Santalol, a terpenoid found in sandalwood oil, has been shown to inhibit cancer cell growth in vitro by inducing apoptosis. This study was performed to…”
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A potential CARB-pharmacophore for antineoplastic activity: Part 1 by Witczak, Zbigniew J., Poplawski, Tomasz, Czubatka, Anna, Sarnik, Joanna, Tokarz, Pawel, VanWert, Adam L., Bielski, Roman

“…Diverse functionalized representatives of various classes of sugars, such as thio-, anhydro-, and sulfamido-sugars and myo-inositol oxide, were synthesized and…”
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Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics by Wolman, Aaron T, Gionfriddo, Michael R, Heindel, Gregory A, Mukhija, Paran, Witkowski, Sarah, Bommareddy, Ajay, Vanwert, Adam L

“…Transporters are major determinants of the disposition of xenobiotics and endogenous chemicals in the body. Organic anion transporter 3 (Oat3) functions in the…”
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Synthesis and Characterization of a Copper‐Based Macrocyclic Chelate for Quantitation and Sequestration of Oxalate: the Major Component of Kidney Stones by VanWert, Adam L, Hensley, Jayden L, Hontz, David S, Torsiello, Maria L, Venditto, Michael L, Luchetta, Jared L, Lucent, Del L, Terzaghi, William L

“…Background Roughly eighty percent of kidney stones are calcium oxalate‐based. Oxalate is found both in diet and synthesized in the liver. Furthermore,…”
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Akt/survivin pathway inhibition enhances the apoptotic cell death-induced by alpha-santalol in human prostate cancer cells by Bommareddy, Ajay, McGlynn, Danielle, Lewis, Marissa, Lockus, Lauren, Seward, Jonathan, Hong, Ka Lok, VanWert, Adam L., Dwivedi, Chandradhar

“…We have shown previously that alpha-santalol, a major component of sandalwood oil inhibits growth of cultured prostate cancer cells in vitro by causing…”
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Synthesis and Pharmacology of Ethylphenidate Enantiomers:  The Human Transesterification Metabolite of Methylphenidate and Ethanol by Patrick, Kennerly S, Williard, Robin L, VanWert, Adam L, Dowd, Justin J, Oatis, John E, Middaugh, Lawrence D

“…Ethanol elevates methylphenidate (1) plasma concentrations and yields the metabolite ethylphenidate (2). The therapeutic implications are under investigation…”
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Abstract 3713: Chemoprevention of prostate carcinogenesis in TRAMP mice by α-santalol by causing cell cycle arrest and induction of apoptosis by Bommareddy, Ajay, Eggelston, William, Prelewicz, Stacy, Antal, Andrea, VanWert, Adam L., Patel, Hiral, Chinikaylo, Aleona, Gutierrez, Linda S., Sreevidya, Santha, Dwivedi, Chandradhar

“…α-santalol, a major component of sandalwood oil inhibits growth of cultured prostate cancer cells in vitro by causing apoptosis. The present study was…”
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Abstract 611: Alpha-santalol, a chemopreventive agent induces apoptosis in human prostate cancer cells by causing caspase-3 activation by Bommareddy, Ajay, Rule, Brittny, VanWert, Adam L., Santha, Sreevidya, Dwivedi, Chandradhar

“…The anticancer effects of α-santalol, a major component of sandalwood oil, have been reported against the development of certain cancers such as skin cancer…”
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