Search Results - The Feinstein Institute for Medical Research

Altered leukocyte gene expression after traumatic spinal cord injury: clinical implications by Herman, Paige, Bloom, Ona

“…In addition to changes in motor and sensory function, individuals with spinal cord injury (SCI) experience immunological changes. These changes are clinically…”
Get full text

Characterization of inflammation and insulin resistance in high‐fat diet‐induced male C57BL/6J mouse model of obesity by Avtanski, Dimiter, Pavlov, Valentin A., Tracey, Kevin J., Poretsky, Leonid

“…Background Animal models of diet‐induced obesity (DIO) are commonly used in medical research for mimicking human diseases. There is no universal animal model,…”
Get full text

ERRATUM

Get full text

Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair by Bucala, R, Spiegel, L A, Chesney, J, Hogan, M, Cerami, A

“…The host response to tissue injury requires a complex interplay of diverse cellular, humoral, and connective tissue elements. Fibroblasts participate in this…”
Get full text

Curcumin is an in vivo inhibitor of angiogenesis by Arbiser, J L, Klauber, N, Rohan, R, van Leeuwen, R, Huang, M T, Fisher, C, Flynn, E, Byers, H R

“…Curcumin is a small-molecular-weight compound that is isolated from the commonly used spice turmeric. In animal models, curcumin and its derivatives have been…”
Get full text

Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates by Garbe, T R, Hibler, N S, Deretic, V

“…Mycobacterium tuberculosis is a significant human pathogen capable of replicating in mononuclear phagocytic cells. Exposure to reactive oxygen and nitrogen…”
Get full text

Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes by Fu, T M, Ulmer, J B, Caulfield, M J, Deck, R R, Friedman, A, Wang, S, Liu, X, Donnelly, J J, Liu, M A

“…MHC class I molecule-restricted cytotoxic T-lymphocyte (CTL) responses are induced following either intramuscular (i.m.) injection of a DNA plasmid encoding…”
Get full text

Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk by Zimmerman, P A, Buckler-White, A, Alkhatib, G, Spalding, T, Kubofcik, J, Combadiere, C, Weissman, D, Cohen, O, Rubbert, A, Lam, G, Vaccarezza, M, Kennedy, P E, Kumaraswami, V, Giorgi, J V, Detels, R, Hunter, J, Chopek, M, Berger, E A, Fauci, A S, Nutman, T B, Murphy, P M

“…CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5…”
Get full text

Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions by Schreiber, V, Moog-Lutz, C, Régnier, C H, Chenard, M P, Boeuf, H, Vonesch, J L, Tomasetto, C, Rio, M C

“…The Lasp-1 gene, which has been localized to the q12-q21 region of human chromosome 17, is amplified and overexpressed in human breast cancers. In addition to…”
Get full text

Heme oxygenase-2 is neuroprotective in cerebral ischemia by Doré, S, Sampei, K, Goto, S, Alkayed, N J, Guastella, D, Blackshaw, S, Gallagher, M, Traystman, R J, Hurn, P D, Koehler, R C, Snyder, S H

“…Heme oxygenase (HO) is believed to be a potent antioxidant enzyme in the nervous system; it degrades heme from heme-containing proteins, giving rise to carbon…”
Get full text

A novel protease homolog differentially expressed in breast and ovarian cancer by Anisowicz, A, Sotiropoulou, G, Stenman, G, Mok, S C, Sager, R

“…Using differential display (DD), we discovered a new member of the serine protease family of protein-cleaving enzymes, named protease M. The gene is most…”
Get full text

Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice by Corry, D B, Grünig, G, Hadeiba, H, Kurup, V P, Warnock, M L, Sheppard, D, Rennick, D M, Locksley, R M

“…The pathogenesis of asthma is believed to reflect antigen-induced airway inflammation leading to the recruitment of eosinophils and activation of mast cells…”
Get full text

An essential role for macrophage migration inhibitory factor (MIF) in angiogenesis and the growth of a murine lymphoma by Chesney, J, Metz, C, Bacher, M, Peng, T, Meinhardt, A, Bucala, R

“…Macrophage migration inhibitory factor (MIF) has been shown to counterregulate glucocorticoid action and to play an essential role in the activation of…”
Get full text

Elevated expression of transforming growth factor-beta in adipose tissue from obese mice by Samad, F, Yamamoto, K, Pandey, M, Loskutoff, D J

“…Tumor necrosis factor-alpha (TNF-alpha) is chronically elevated in the adipose tissue from obese humans and mice. This increase in TNF-alpha contributes to the…”
Get full text

Mdm2: the ups and downs by Juven-Gershon, T, Oren, M

Get full text

Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase by Burnett, A L, Nelson, R J, Calvin, D C, Liu, J X, Demas, G E, Klein, S L, Kriegsfeld, L J, Dawson, V L, Dawson, T M, Snyder, S H

“…Nitric oxide (NO) has been implicated as a mediator of penile erection, because the neuronal isoform of NO synthase (NOS) is localized to the penile…”
Get full text

Thalidomide treatment reduces tumor necrosis factor alpha production and enhances weight gain in patients with pulmonary tuberculosis by Tramontana, J M, Utaipat, U, Molloy, A, Akarasewi, P, Burroughs, M, Makonkawkeyoon, S, Johnson, B, Klausner, J D, Rom, W, Kaplan, G

“…The monocyte-derived cytokine, tumor necrosis factor alpha (TNF alpha), is essential for host immunity, but overproduction of this cytokine may have serious…”
Get full text

Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production by Rodrigues, C M, Fan, G, Wong, P Y, Kren, B T, Steer, C J

“…The hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat cholestatic liver diseases. Interestingly,…”
Get full text

Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model by Fiala, M, Zhang, L, Gan, X, Sherry, B, Taub, D, Graves, M C, Hama, S, Way, D, Weinand, M, Witte, M, Lorton, D, Kuo, Y M, Roher, A E

“…Aside from numerous parenchymal and vascular deposits of amyloid beta (A beta) peptide, neurofibrillary tangles, and neuronal and synaptic loss, the…”
Get full text

T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents by Honeyman, M C, Stone, N L, Harrison, L C

“…The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides in autoantigens have potential…”
Get full text