Search Results - Tambralli, A.

NETs in APS: Current Knowledge and Future Perspectives by Tambralli, Ajay, Gockman, Kelsey, Knight, Jason S.

“…Purpose of Review Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease that is primarily treated with anticoagulation. Better understanding the…”
Get full text

Safety and efficacy of rituximab in childhood-onset systemic lupus erythematosus and other rheumatic diseases by Tambralli, Ajay, Beukelman, Timothy, Cron, Randy Quentin, Stoll, Matthew Laurence

“…Rituximab (RTX) has been used to treat many pediatric autoimmune conditions. We investigated the safety and efficacy of RTX in a variety of pediatric…”
Get full text

Cell infiltration and growth in a low density, uncompressed three-dimensional electrospun nanofibrous scaffold by Blakeney, Bryan A, Tambralli, Ajay, Anderson, Joel M, Andukuri, Adinarayana, Lim, Dong-Jin, Dean, Derrick R, Jun, Ho-Wook

“…Abstract A limiting factor of traditional electrospinning is that the electrospun scaffolds consist entirely of tightly packed nanofiber layers that only…”
Get full text

Pediatric antiphospholipid syndrome: clinical features and therapeutic interventions in a single center retrospective case series by Madison, Jacqueline A, Gockman, Kelsey, Hoy, Claire, Tambralli, Ajay, Zuo, Yu, Knight, Jason S

“…Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease characterized by the presence of circulating antiphospholipid antibodies and either…”
Get full text

High Doses of Infliximab in the Management of Juvenile Idiopathic Arthritis by TAMBRALLI, Ajay, BEUKELMAN, Timothy, WEISER, Peter, ATKINSON, Thomas Prescott, CRON, Randy Quentin, STOLL, Matthew Laurence

“…To review our experiences with high-dose infliximab (IFX) to treat juvenile idiopathic arthritis (JIA). We routinely use high doses of IFX (10-20 mg/kg) in…”
Get full text

Osteogenic Differentiation of Human Mesenchymal Stem Cells Directed by Extracellular Matrix-Mimicking Ligands in a Biomimetic Self-Assembled Peptide Amphiphile Nanomatrix by Anderson, Joel M, Kushwaha, Meenakshi, Tambralli, Ajay, Bellis, Susan L, Camata, Renato P, Jun, Ho-Wook

“…This study investigated the ability of nanoscale, biomimetic peptide amphiphile (PA) scaffolds inscribed with specific cellular adhesive ligands to direct the…”
Get full text

Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome by NaveenKumar, Somanathapura K., Tambralli, Ajay, Fonseca, Bruna Mazetto, Yalavarthi, Srilakshmi, Liang, Wenying, Hoy, Claire K., Sarosh, Cyrus, Rysenga, Christine E., Ranger, Caroline H., Vance, Caroline E., Madison, Jacqueline A., Orsi, Fernanda A., Sood, Suman L., Schaefer, Jordan K., Zuo, Yu, Knight, Jason S.

“…Many patients with antiphospholipid syndrome had decreased ectonucleotidase activity on neutrophils and platelets, which enabled extracellular nucleotides to…”
Get full text

Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome by Tambralli, Ajay, Harbaugh, Alyssa, NaveenKumar, Somanathapura K, Radyk, Megan D, Rysenga, Christine E, Sabb, Kaitlyn, Hurley, Julia M, Sule, Gautam J, Yalavarthi, Srilakshmi, Estes, Shanea K, Hoy, Claire, Smith, Tristin, Sarosh, Cyrus, Madison, Jacqueline A, Schaefer, Jordan K, Sood, Suman L, Zuo, Yu, Sawalha, Amr H, Lyssiotis, Costas A, Knight, Jason S

“…Neutrophil hyperactivity and neutrophil extracellular trap release (NETosis) appear to play important roles in the pathogenesis of the thromboinflammatory…”
Get full text

Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps by Kmeťová, Katarína, Lonina, Elena, Yalavarthi, Srilakshmi, Levine, Jerrold S., Hoy, Claire K., Sarosh, Cyrus, Gockman, Kelsey, Morris, Alexandra E., Tambralli, Ajay, Madison, Jacqueline A., Zuo, Yu, Subang, Rebecca, Rauch, Joyce, Knight, Jason S.

“…Beta-2 glycoprotein I (β2GPI) is a phospholipid-binding plasma protein and prominent autoantigen in antiphospholipid syndrome (APS). Here, we tested the…”
Get full text

Utilizing type I interferon expression in the identification of antiphospholipid syndrome subsets by Cecchi, Irene, Radin, Massimo, Rodríguez-Carrio, Javier, Tambralli, Ajay, Knight, Jason S, Sciascia, Savino

“…Antiphospholipid Syndrome (APS) is a systemic autoimmune disease with a complex multifactorial pathogenesis, combining genetic background, traditional…”
Get more information

Predictors and Interrelationship of Patient‐Reported Outcomes in Antiphospholipid Syndrome: A Cross‐Sectional Study by Weiner, Julia K., Smith, Tristin, Hoy, Claire K., Sarosh, Cyrus, Madison, Jacqueline A., Ambati, Amala, Tambralli, Ajay, Peters, Noah, Packel, Corinne, Gockman, Kelsey, Zuo, Yu, Briceño, Emily M., Nagaraja, Vivek, Knight, Jason S.

“…Objective This study assessed patient‐reported outcomes (PROs) in individuals with persistently positive antiphospholipid antibodies (aPL) to better understand…”
Get full text

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice by Liu, Chao, Yalavarthi, Srilakshmi, Tambralli, Ajay, Zeng, Lixia, Rysenga, Christine E, Alizadeh, Nikoo, Hudgins, Lucas, Liang, Wenying, NaveenKumar, Somanathapura K, Shi, Hui, Shelef, Miriam A, Atkins, Kevin B, Pennathur, Subramaniam, Knight, Jason S

“…While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-associated complications, such as dysfunctional wound healing, their…”
Get full text

A hybrid biomimetic nanomatrix composed of electrospun polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants by Andukuri, Adinarayana, Kushwaha, Meenakshi, Tambralli, Ajay, Anderson, Joel M., Dean, Derrick R., Berry, Joel L., Sohn, Young Doug, Yoon, Young-Sup, Brott, Brigitta C., Jun, Ho-Wook

“…Current cardiovascular therapies are limited by the loss of endothelium, restenosis and thrombosis. The goal of this study was to develop a biomimetic hybrid…”
Get full text

A hybrid biomimetic scaffold composed of electrospun polycaprolactone nanofibers and self-assembled peptide amphiphile nanofibers by Tambralli, Ajay, Blakeney, Bryan, Anderson, Joel, Kushwaha, Meenakshi, Andukuri, Adinarayana, Dean, Derrick, Jun, Ho-Wook

“…Nanofibrous electrospun poly (epsilon-caprolactone) (ePCL) scaffolds have inherent structural advantages, but lack of bioactivity has limited their usefulness…”
Get more information

A bio-inspired hybrid nanosack for graft vascularization at the omentum by Hwang, Patrick T.J., Lim, Dong-Jin, Fee, Timothy, Alexander, Grant C., Tambralli, Ajay, Andukuri, Adinarayana, Tian, Liqun, Cui, Wanxing, Berry, Joel, Gilbert, Shawn R., Jun, Ho-Wook

“…[Display omitted] For three-dimensional tissue engineering scaffolds, the major challenges of hydrogels are poor mechanical integrity and difficulty in…”
Get full text

Tgf-β and intervertebral disc development by Cox, Megan K., Tambralli, Ajay, Sohn, Philip, Jun, Ho-Wook, Serra, Rosa

Get full text

A Novel Approach for Design, Implementation and Construction of Low Density Parity Check (LDPC) Memory by Harshitha, B., Karthik, M., Tambralli, Vinayak

“…Memory is an important part of any digital circuit in which data is stored and retrieved. Technology scaling, lower operating voltages and high integration…”
Get full text