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Ciclosporin Use During Pregnancy by Paziana, Karolina, Del Monaco, Magaly, Cardonick, Elyce, Moritz, Michael, Keller, Matthew, Smith, Bruce, Coscia, Lisa, Armenti, Vincent

“…Ciclosporin (cyclosporine) is an immunosuppressive drug first approved for use in organ transplantation to prevent rejection. Ciclosporin is also known to be…”
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Transplantation for Acute Liver Failure in Patients Exposed to NSAIDs or Paracetamol (Acetaminophen): The Multinational Case-Population SALT Study by Gulmez, Sinem Ezgi, Larrey, Dominique, Pageaux, Georges-Philippe, Lignot, Severine, Lassalle, Régis, Jové, Jérémy, Gatta, Angelo, McCormick, P. Aiden, Metselaar, Harold J., Monteiro, Estela, Thorburn, Douglas, Bernal, William, Zouboulis-Vafiadis, Irene, de Vries, Corinne, Perez-Gutthann, Susana, Sturkenboom, Miriam, Bénichou, Jacques, Montastruc, Jean-Louis, Horsmans, Yves, Salvo, Francesco, Hamoud, Fatima, Micon, Sophie, Droz-Perroteau, Cécile, Blin, Patrick, Moore, Nicholas

“…Background Most NSAIDs are thought to be able to cause hepatic injury and acute liver failure (ALF), but the event rates of those leading to transplantation…”
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Newly Initiated Opioid Treatment and the Risk of Fall-Related Injuries: A Nationwide, Register-Based, Case-Crossover Study in Sweden by Söderberg, Karin C., Laflamme, Lucie, Möller, Jette

“…Background There is growing epidemiological evidence that opioids may increase the risk of unintentional injuries and it is plausible that the time of…”
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Postoperative Analgesia in Elderly Patients by Falzone, Elisabeth, Hoffmann, Clément, Keita, Hawa

“…Elderly people represent the fastest-growing segment of our society and undergo surgery more frequently than other age groups. Effective postoperative…”
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Cytochrome P450-Mediated Changes in Oxycodone Pharmacokinetics/Pharmacodynamics and Their Clinical Implications by Söderberg Löfdal, Karin C., Andersson, Marine L., Gustafsson, Lars L.

“…In recent years the use of the opioid oxycodone has increased markedly and replacing morphine as the first-line choice of opioid in several countries. There…”
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Adverse Drug Reactions to Gabapentin and Pregabalin: A Review of the French Pharmacovigilance Database by Fuzier, Régis, Serres, Isabelle, Guitton, Emmanuelle, Lapeyre-Mestre, Maryse, Montastruc, Jean-Louis

“…Background Gabapentin and pregabalin are widely used as antineuropathic pain drugs. Their use is also associated with the development of adverse drug reactions…”
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The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis by Santana-Codina, Naiara, Gikandi, Ajami, Mancias, Joseph D

“…Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage complex,…”
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Hemoglobin: Structure, Function and Allostery by Ahmed, Mostafa H, Ghatge, Mohini S, Safo, Martin K

“…This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact hemoglobin (Hb) primary physiological function of oxygen binding and…”
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Insulin Resistance, Obesity and Lipotoxicity by Yazıcı, Dilek, Sezer, Havva

“…Lipotoxicity , originally used to describe the destructive effects of excess fat accumulation on glucose metabolism, causes functional impairments in several…”
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Inflammation, Frailty and Cardiovascular Disease by Soysal, Pinar, Arik, Ferhat, Smith, Lee, Jackson, Sarah E, Isik, Ahmet Turan

“…Chronic inflammation, which is called "inflamm-aging" , is characterized by an increased level of inflammatory cytokines in response to physiological and…”
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ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) by Kellner, Manuela, Noonepalle, Satish, Lu, Qing, Srivastava, Anup, Zemskov, Evgeny, Black, Stephen M

“…The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the…”
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Tackling Threats and Future Problems of Multidrug-Resistant Bacteria by Medina, Eva, Pieper, Dietmar Helmut

“…With the advent of the antibiotic era, the overuse and inappropriate consumption and application of antibiotics have driven the rapid emergence of…”
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The Definition and Prevalence of Obesity and Metabolic Syndrome by Engin, Atilla

“…Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total…”
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Lung Cancer Statistics by Torre, Lindsey A, Siegel, Rebecca L, Jemal, Ahmedin

“…Lung cancer is the leading cause of cancer death among both men and women in the United States. It is also the leading cause of cancer death among men and the…”
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High-Intensity Interval Training, Solutions to the Programming Puzzle: Part I: Cardiopulmonary Emphasis by Buchheit, Martin, Laursen, Paul B.

“…High-intensity interval training (HIT), in a variety of forms, is today one of the most effective means of improving cardiorespiratory and metabolic function…”
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Impact of Salt Intake on the Pathogenesis and Treatment of Hypertension by Rust, Petra, Ekmekcioglu, Cem

“…Excessive dietary salt (sodium chloride) intake is associated with an increased risk for hypertension, which in turn is especially a major risk factor for…”
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Health and Racial Disparity in Breast Cancer by Yedjou, Clement G, Sims, Jennifer N, Miele, Lucio, Noubissi, Felicite, Lowe, Leroy, Fonseca, Duber D, Alo, Richard A, Payton, Marinelle, Tchounwou, Paul B

“…Breast cancer is the most common noncutaneous malignancy and the second most lethal form of cancer among women in the United States. It currently affects more…”
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Epithelial-Mesenchymal Transition (EMT) and Prostate Cancer by Odero-Marah, Valerie, Hawsawi, Ohuod, Henderson, Veronica, Sweeney, Janae

“…Typically the normal epithelial cells are a single layer, held tightly by adherent proteins that prevent the mobilization of the cells from the monolayer…”
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Safety Profile of Modafinil Across a Range of Prescribing Indications, Including Off-Label Use, in a Primary Care Setting in England: Results of a Modified Prescription-Event Monitoring Study by Davies, Miranda, Wilton, Lynda, Shakir, Saad

“…Background Modafinil (Provigil) was marketed in the UK in 1998 to promote wakefulness in the treatment of narcolepsy. In April 2004, the licence was extended…”
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Sarcopenia and Its Impact on Quality of Life by Tsekoura, Maria, Kastrinis, Alexandros, Katsoulaki, Marianna, Billis, Evdokia, Gliatis, John

“…Sarcopenia is recognized as a major health problem among older adults. This syndrome is associated with serious health consequences in terms of frailty,…”
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