Search Results - Spektrum Akademischer Verlag
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A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays
Published in ALTEX (01-01-2018)“…The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test battery covering most of the relevant adverse outcome…”
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DarT: The embryo test with the Zebrafish Danio rerio--a general model in ecotoxicology and toxicology
Published in ALTEX, alternatives to animal experimentation (2002)“…The acute fish test is an animal test whose ecotoxicological relevance is worthy of discussion. The primary aim of protection in ecotoxicology is the…”
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The embryonic stem cell test for the early selection of pharmaceutical compounds
Published in ALTEX, alternatives to animal experimentation (2007)“…Potential teratogenicity is a major consideration in the development of pharmaceutical substances. Currently its assessment involves large numbers of animal…”
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Fast network oscillations in the hippocampus: Phenomena, mechanisms and open questions at the interface of cellular and systemic neurosciences
Published in Neuroforum (01-03-2013)“…Neuronal networks often express coherent oscillatory activity. These rhythms can provide a temporal reference for the activity of single neurons and allow the…”
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Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretion
Published in ALTEX, alternatives to animal experimentation (2007)“…Human hepatocytes are the in vitro system of choice to study drug-induced processes in man. Here, we present HEPAC(2): a standardised and validated culture…”
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Laktosefreie Milchprodukte durch β-Galaktosidasen der nächsten Generation
Published in Biospektrum (2012)“…Zusammenfassung In this work, a metagenomic library in Escherichia coli was screened for clones with β-galactosidase activity. The metagenomic enzymes having…”
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Optimisation of the EpiDerm test protocol for the upcoming ECVAM validation study on in vitro skin irritation tests
Published in ALTEX, alternatives to animal experimentation (2004)“…An ECVAM-funded prevalidation study (PV) was conducted during 1999 and 2000 to identify in vitro tests capable of reliably distinguishing between skin…”
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Multivariate decoding of fMRI data: Towards a content-based cognitive neuroscience
Published in Neuroforum (01-03-2012)“…The advent of functional magnetic resonance imaging (fMRI) of brain function 20 years ago has provided a new methodology for non-invasive measurement of brain…”
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Experimental models of spatial neglect: Studies in human and nonhuman primates
Published in Neuroforum (01-03-2012)“…Spatial neglect is a debilitating neuropsychological disorder that is characterized by an impaired or lost ability to explore the space contralateral to the…”
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Neuronal cell culture from human embryonic stem cells as in vitro model for neuroprotection
Published in ALTEX, alternatives to animal experimentation (2007)“…In the context of efficacy testing of pharmacological compounds in animal models, replacement of some of these models with a relevant human in vitro system…”
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Olfaction in insects: The primary processes of odor recognition and coding
Published in Neuroforum (18-09-2011)“…Summary Odorants provide insects with crucial information about their environment and trigger various insect behaviors. A remarkably sensitive and selective…”
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The melody of the immature brain
Published in Neuroforum (01-03-2013)“…The periodicity of brain activity became obvious even after the first attempt to capture it, with Hans Berger noting in 1929 that the “electroencephalogram…”
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Connectomics: novel methods for the dense reconstruction of neuronal circuits
Published in Neuroforum (01-03-2013)“…The nervous system is characterized by extremely complex cell-to-cell interactions which primarily occur via chemical synapses. Mapping the structure of these…”
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The endogenous cannabinoid system
Published in Neuroforum (01-12-2012)“…The hemp plant Cannabis sativa has been cultivated for thousands of years and is used as a medical plant and intoxicant. Scientific research on the…”
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Optogenetics: a new method for the causal analysis of neuronal networks in vivo
Published in Neuroforum (01-12-2012)“…The causal analysis of neuronal network function requires selective manipulations of genetically defined neuronal subpopulations in the intact living brain…”
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Shapeshifting for memory: Biochemical and electrical signaling in dendritic spines
Published in Neuroforum (27-03-2011)“…One of the biggest remaining mysteries of science is inside our heads: how does nature wire up a high-performance computer without having a detailed blueprint…”
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