Search Results - Nourshargh, S.

Leukocyte Migration into Inflamed Tissues by Nourshargh, Sussan, Alon, Ronen

“…Leukocyte migration through activated venular walls is a fundamental immune response that is prerequisite to the entry of effector cells such as neutrophils,…”
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Breaching multiple barriers: leukocyte motility through venular walls and the interstitium by Nourshargh, Sussan, Hordijk, Peter L, Sixt, Michael

“…Key Points The shuttling of leukocytes between the blood stream and interstitial tissues involves different locomotion strategies that are governed by locally…”
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Role of neutrophil elastase in LTB 4 ‐induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice by Young, R E, Voisin, M‐B, Wang, S, Dangerfield, J, Nourshargh, S

“…Background and purpose: The serine protease neutrophil elastase (NE) appears to regulate inflammatory responses at multiple levels but its role in leukocyte…”
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Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo by Tharp, William G., Yadav, R., Irimia, D., Upadhyaya, A., Samadani, A., Hurtado, O., Liu, S‐Y., Munisamy, S., Brainard, D. M., Mahon, M. J., Nourshargh, S., Oudenaarden, A., Toner, M. G., Poznansky, Mark C.

“…We report for the first time that primary human neutrophils can undergo persistent, directionally biased movement away from a chemokine in vitro and in vivo,…”
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Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity by Beyrau, Martina, Bodkin, Jennifer Victoria, Nourshargh, Sussan

“…Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional…”
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The melanocortin MC 1 receptor agonist BMS‐470539 inhibits leucocyte trafficking in the inflamed vasculature by Leoni, G, Voisin, M‐B, Carlson, K, Getting, SJ, Nourshargh, S, Perretti, M

“…Background and purpose:  Over three decades of research evaluating the biology of melanocortin (MC) hormones and synthetic peptides, activation of the MC type…”
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The melanocortin MC1 receptor agonist BMS‐470539 inhibits leucocyte trafficking in the inflamed vasculature by Leoni, G, Voisin, M‐B, Carlson, K, Getting, SJ, Nourshargh, S, Perretti, M

“…Background and purpose:  Over three decades of research evaluating the biology of melanocortin (MC) hormones and synthetic peptides, activation of the MC type…”
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Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF by Finsterbusch, Michaela, Voisin, Mathieu-Benoit, Beyrau, Martina, Williams, Timothy John, Nourshargh, Sussan

“…Microvascular plasma protein leakage is an essential component of the inflammatory response and serves an important function in local host defense and tissue…”
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Getting to the site of inflammation: the leukocyte adhesion cascade updated by Cybulsky, Myron I, Nourshargh, Sussan, Ley, Klaus, Laudanna, Carlo

“…Neutrophil recruitment, lymphocyte recirculation and monocyte trafficking all require adhesion and transmigration through blood-vessel walls. The traditional…”
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Role of neutrophil elastase in LTB4‐induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice by Young, R E, Voisin, M‐B, Wang, S, Dangerfield, J, Nourshargh, S

“…Background and purpose: The serine protease neutrophil elastase (NE) appears to regulate inflammatory responses at multiple levels but its role in leukocyte…”
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Endothelial Cell Junctional Adhesion Molecules: Role and Regulation of Expression in Inflammation by Reglero-Real, Natalia, Colom, Bartomeu, Bodkin, Jennifer Victoria, Nourshargh, Sussan

“…Endothelial cells line the lumen of all blood vessels and play a critical role in maintaining the barrier function of the vasculature. Sealing of the vessel…”
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Reverse Migration of Neutrophils: Where, When, How, and Why? by Nourshargh, Sussan, Renshaw, Stephen A, Imhof, Beat A

“…Neutrophil migration to injured and pathogen-infected tissues is a fundamental component of innate immunity. An array of cellular and molecular events mediate…”
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PECAM-1: A Multi-Functional Molecule in Inflammation and Vascular Biology by Woodfin, Abigail, Voisin, Mathieu-Benoit, Nourshargh, Sussan

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1 or CD31) is a molecule expressed on all cells within the vascular compartment, being expressed to…”
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Doppler compensation for cavity-based atom interferometry by Nourshargh, Rustin, Hedges, Sam, Langlois, Mehdi, Bongs, Kai, Holynski, Michael

“…We propose and demonstrate a scheme for Doppler compensated optical cavity enhancement of atom interferometers at significantly increased mode diameters. This…”
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Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation by Gittens, Beatrice R, Bodkin, Jennifer V, Nourshargh, Sussan, Perretti, Mauro, Cooper, Dianne

“…In vivo and ex vivo imaging were used to investigate the function of galectin-3 (Gal-3) during the process of leukocyte recruitment to the inflamed…”
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Neutrophil Transmigration: Emergence of an Adhesive Cascade within Venular Walls by Voisin, Mathieu-Benoit, Nourshargh, Sussan

“…Recruitment of neutrophils from the blood circulation to sites of infection or injury is a key innate immune response against invading pathogens and tissue…”
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Regulation of ICAM-1 in human neutrophils by Vignarajah, Muralie, Wood, Alexander J T, Nelmes, Elizabeth, Subburayalu, Julien, Herre, Jurgen, Nourshargh, Sussan, Summers, Charlotte, Chilvers, Edwin R, Farahi, Neda

“…Intercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role in the immune response to pathogens. The expression pattern of…”
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Learning in motion: pericytes instruct migrating innate leukocytes by Alon, Ronen, Nourshargh, Sussan

“…During sterile inflammation, emigrating leukocytes sequentially engage subsets of pericytes associated with blood vessels and acquire adhesive, migratory and…”
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Neutrophil trafficking to lymphoid tissues: physiological and pathological implications by Voisin, Mathieu‐Benoit, Nourshargh, Sussan

“…Recent advances have provided evidence for the involvement of neutrophils in both innate and adaptive immunity, robustly challenging the old dogma that…”
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Leukocyte Trafficking: Time to Take Time Seriously by Reglero-Real, Natalia, Rolas, Loïc, Nourshargh, Sussan

“…Leukocyte trafficking is a key component of steady-state tissue homing and in mounting an inflammatory response. Two recent publications in Immunity by He…”
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